Biliary excretion of taurolithocholate-sulfate and temocaprilat in cholestatic rats induced by bile duct-ligation and ethinylestradiol
| Autor: | Toshiki Onishi, Kou Nishikawa, Hajime Takikawa, Atsuko Toda, Makoto Hojo, Hiroyuki Tanaka, Tatsuyuki Marumo, Hideki Tachizawa, Naoyo Sano, Naoko Hanawa |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Hepatology Organic anion transporter 1 biology Multidrug resistance-associated protein 2 Transporter medicine.disease digestive system Temocapril Excretion Infectious Diseases Endocrinology Cholestasis Internal medicine Ethinylestradiol medicine biology.protein medicine.drug Temocaprilat |
| Zdroj: | Hepatology Research. 24:136-140 |
| ISSN: | 1386-6346 |
| DOI: | 10.1016/s1386-6346(02)00028-1 |
| Popis: | Down-regulation of multidrug resistance protein 2 (Mrp2), a major canalicular organic anion transporter, has been reported in various cholestatic models and in patients with cholestasis. In the present study, biliary excretion of taurolithocholate-sulfate and temocaprilat, substrates of Mrp2, was studied in bile duct-ligated rats and in cholestatic rats induced by ethinylestradiol (EE). Biliary excretion of temocaprilat was more markedly decreased in bile duct-ligated rats than that of taurolithocholate-sulfate. In contrast, biliary excretion of both compounds were similarly inhibited in EE-treated rat. Such difference of the degree of inhibition may have been caused by the different degree of the inhibition of unknown canalicular transporters other than Mrp2 in bile duct-ligated rats. |
| Databáze: | OpenAIRE |
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