Serological Response of Japanese Children and Old People to Japanese B Encephalitis Mouse Brain Vaccine
| Autor: | Minoru Matumoto, Albert B. Sabin, D. R. Ginder, R. W. Schlesinger |
|---|---|
| Rok vydání: | 1947 |
| Předmět: |
Vaccines
biology business.industry Brain Outbreak Japanese encephalitis medicine.disease Virology General Biochemistry Genetics and Molecular Biology Neutralization Serology Vaccination Japanese B Encephalitis Mice Immunology biology.protein Animals Encephalitis Humans Medicine Antibody Child Encephalitis Japanese business |
| Zdroj: | Experimental Biology and Medicine. 65:135-140 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-65-15890 |
| Popis: | SummaryJapanese children, 3 to 5 years old, and people, over 60 years of age, living in the endemic region of Okayama, Japan, were given commercial Japanese B encephalitis mouse brain vaccine—2 doses of 1 cc each, 6 days apart, and a 3rd dose of 1 cc one month after the first dose in advance of the season when outbreaks of the disease may be expected. None of the children had antibodies before vaccination, and of the 10, who were inoculated with a vaccine having a 50% immunogenic dose (ID30) of 0.013 cc by mouse assay, all had neutralizing antibodies 10 days after the 3rd dose, while only 1 of the 10, who received a vaccine with an ID50 of 0.077 cc, developed a significant neutralization index. However, in a group of 7 old people, without antibodies before inoculation, who received the same dosage of the better vaccine (ID30 of 0.013 cc) none developed neutralizing or complement-fixing antibodies. Complement-fixing antibodies for the mouse brain component appeared as well as for the Japanese B virus conta... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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