Perivascular epithelioid cell tumor (PEComa) of the pancreas: Immunoelectron microscopy and review of the literature
| Autor: | Kenichi Hirabayashi, Yoshiaki Kawaguchi, Toshihide Imaizumi, Robert Yoshiyuki Osamura, Shoichi Dowaki, Naoya Nakamura, Sadaaki Hori, Hiroshi Kajiwara, Tomohiro Yamashita |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Perivascular Epithelioid Cell Neoplasms Immunoelectron microscopy Adipose tissue Biology Perivascular Epithelioid Cell Pancreaticoduodenectomy Pathology and Forensic Medicine Tuberous sclerosis Antigens Neoplasm Biomarkers Tumor medicine Humans Melanosomes Epithelioid Cells General Medicine Middle Aged medicine.disease Immunohistochemistry Actins Neoplasm Proteins Pancreatic Neoplasms Treatment Outcome medicine.anatomical_structure Female Pancreas Melanoma-Specific Antigens Epithelioid cell |
| Zdroj: | Pathology International. 59:650-655 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2009.02421.x |
| Popis: | A perivascular epithelioid tumor (PEComa) is a rare tumor probably arising from the perivascular epithelioid cells. Only three cases of pancreatic PEComa have been reported in the English-language literature. The present report describes an extremely rare case of pancreatic PEComa. A 47-year-old Japanese woman complained of lower abdominal pain and a well-demarcated solid tumor was found in the pancreatic head. There was no history of tuberous sclerosis complexes. Pylorus-preserving pancreaticoduodenectomy was thus performed. There was a well-demarcated, solid tumor measuring 17 mm in the pancreatic head. The tumor was composed of a diffuse proliferation of epithelioid tumor cells with many blood vessels but no adipose tissue. The tumor cells expressed HMB45 and alpha-smooth muscle actin. Ultrastructurally, the tumor cells possessed many membrane-bound granules that were positive for HMB45 on immunoelectron microscopy. The results of immunoelectron microscopy show that some PEComas possess not only typical melanosomes or premelanosomes but also aberrant melanosomes. |
| Databáze: | OpenAIRE |
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