Evaluation of the diagnostic utility of the TRH-induced TSH response in psychiatric disorders
| Autor: | A. J. Prange, Peter T. Loosen, J. C. Garbutt |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male endocrine system Psychosis medicine.medical_specialty endocrine system diseases Diagnostico diferencial Thyrotropin Borderline Personality Disorder medicine Humans Pharmacology (medical) Psychiatry Borderline personality disorder Thyrotropin-Releasing Hormone Depression (differential diagnoses) Depressive Disorder Mental Disorders General Medicine medicine.disease Psychiatry and Mental health Alcoholism Schizophrenia Psychiatric diagnosis Female Psychology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pharmacopsychiatry. 20(3) |
| ISSN: | 0176-3679 |
| Popis: | To evaluate the diagnostic utility of TSH blunting, the TRH-induced TSH response was measured in 168 normal subjects and 176 psychiatric patients. It was blunted in some acutely depressed, alcoholic, and borderline patients, but not in schizophrenic patients. In both depression and alcoholism the fault also occurred during symptomatic recovery, though with reduced frequency. Although TSH blunting was useful in distinguishing between borderline and schizophrenic patients, its diagnostic utility in identifying or confirming an existing psychiatric disorder appears to be limited. TSH blunting is not specific for any particular psychiatric diagnosis, and its sensitivity generally is low. However, the fault has promising research utility, particularly for study of the biologic interface between depression, alcoholism and borderline personality disorder. Beyond this, further study of the possible trait nature of TSH blunting in both depression and alcoholism appears warranted. |
| Databáze: | OpenAIRE |
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