OVAREX™ MAb-B43.13:IFN-γ Could Improve the Ovarian Tumor Cell Sensitivity to CA125-Specific Allogenic Cytotoxic T Cells
| Autor: | R. Yang, Richard P. Baum, R. Madiyalakan, Birgit Schultes, Antoine A. Noujaim |
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| Rok vydání: | 1997 |
| Předmět: |
endocrine system diseases
Immunology CD1 Mice Nude Antineoplastic Agents Antibodies Monoclonal Murine-Derived Interferon-gamma Mice Ovarian tumor Interleukin 21 Interferon MHC class I Tumor Cells Cultured Genetics medicine Animals Humans Cytotoxic T cell Antigen-presenting cell Ovarian Neoplasms biology Histocompatibility Antigens Class I Histocompatibility Antigens Class II Antibodies Monoclonal Intercellular Adhesion Molecule-1 female genital diseases and pregnancy complications CA-125 Antigen Cancer research biology.protein Interleukin 12 Female T-Lymphocytes Cytotoxic medicine.drug |
| Zdroj: | Hybridoma. 16:41-45 |
| ISSN: | 0272-457X |
| DOI: | 10.1089/hyb.1997.16.41 |
| Popis: | Various immunological parameters were studied in 100 ovarian cancer patients injected with the OVAREX therapeutic vaccine (the functional component of which is anti-CA125 MAb-B43.13) to explain the serendipitous observation of prolonged survival after such treatment. In addition to CA125-specific humoral and cellular responses, interferon-gamma (IFN-gamma) was also found to be induced in those patients receiving the vaccine. In vitro studies indicated that the expression of MHC I, MHC II, and ICAM I in ovarian tumor cells were upregulated in response to IFN-gamma. Such tumor cells were also found to be more sensitive to CA125-specific cytotoxic T cells compared to cells that were not incubated with IFN-gamma. |
| Databáze: | OpenAIRE |
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