Renal Microcystic Tubular Lesions in Two 1Year-old Dogs – An Early Sign of Hereditary Renal Cystadenocarcinoma?
| Autor: | Lars Moe, Frode Lingaas, H. Gamlem, Thora J. Jonasdottir |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty General Veterinary Renal Cystadenocarcinoma business.industry Cystadenocarcinoma Kidney Diseases Cystic Kidney Immunohistochemistry Kidney Neoplasms Pathology and Forensic Medicine Cytokeratin Cystic lesion Dogs Kidney Tubules Renal cysts German Shepherd Dog medicine Animals Keratins Female Dog Diseases business |
| Zdroj: | Journal of Comparative Pathology. 123:218-221 |
| ISSN: | 0021-9975 |
| DOI: | 10.1053/jcpa.2000.0408 |
| Popis: | As a part of a study of early renal changes in renal cystadenocarcinoma (RC), a 5-year-old German shepherd dog and two 1-year-old German shepherd mixed-breed dogs were examined. All three animals had bilateral, microscopic renal cysts, and the 5-year-old dog also had RC. Microscopical examination showed papillary hyperplastic tubular epithelial cells lining the inner wall of the renal cysts in all dogs. These cells showed strong reactivity with a monoclonal antibody against a broad-spectrum type of cytokeratin. The dam of the young dogs had suffered from autosomal dominant inherited RC and nodular dermatofibrosis (ND) syndrome. It is likely that the microscopic renal cystic lesions seen in the young dogs represented an early renal change in the RC/ND syndrome. This suggests that the diagnosis of RC can be made on suspected carriers by microscopical examination of renal biopsies as early as 1 year of age, i.e., before the dogs are used for breeding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect