Four-Year Cost-effectiveness of Cognitive Behavior Therapy for Preventing First-episode Psychosis: The Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial
| Autor: | David Van Den Berg, Nynke Boonstra, Mark van der Gaag, Sara Dragt, Helga K. Ising, Dorien H. Nieman, Tamar Kraan, Joran Lokkerbol, Lex Wunderink, Rianne M. C. Klaassen, Filip Smit, Wim Veling, Don H. Linszen, Judith Rietdijk |
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| Přispěvatelé: | Epidemiology and Data Science, APH - Mental Health, Clinical Psychology, Clinical, Neuro- & Developmental Psychology, Perceptual and Cognitive Neuroscience (PCN), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, Psychiatrie & Neuropsychologie, RS: FHML non-thematic output |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics Cost effectiveness Cost-Benefit Analysis medicine.medical_treatment ECONOMIC-EVALUATION law.invention 0302 clinical medicine prevention Randomized controlled trial law HELP-SEEKING POPULATION Outcome Assessment Health Care psychosis health care economics and organizations Netherlands quality-adjusted life year (QALY) Absolute risk reduction Regular Article Cost-effectiveness analysis RANDOMIZED CONTROLLED-TRIAL Cognitive behavioral therapy Psychiatry and Mental health RELIABILITY Disease Progression Female Psychology ULTRA-HIGH-RISK Adult Risk medicine.medical_specialty Psychosis Adolescent 1ST EPISODE QUESTIONNAIRE ultra-high risk VALIDATION Young Adult 03 medical and health sciences SDG 3 - Good Health and Well-being Early Medical Intervention medicine Humans VALIDITY cost-utility Psychiatry cost-effectiveness METAANALYSIS Cognitive Behavioral Therapy medicine.disease 030227 psychiatry Quality-adjusted life year Early Diagnosis Psychotic Disorders Cognitive therapy 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Schizophrenia Bulletin, 43(2), 365-374. Oxford University Press Ising, H K, Lokkerbol, J, Rietdijk, J, Dragt, S, Klaassen, R M C, Kraan, T, Boonstra, N, Nieman, D H, van den Berg, D P G, Linszen, D H, Wunderink, L, Veling, W, Smit, F & van der Gaag, M 2017, ' Four-Year Cost-effectiveness of Cognitive Behavior Therapy for Preventing First-episode Psychosis : The Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial ', Schizophrenia Bulletin, vol. 43, no. 2, pp. 365-374 . https://doi.org/10.1093/schbul/sbw084 Ising, H K, Lokkerbol, J, Rietdijk, J, Dragt, S, Klaassen, R M C, Kraan, T C, Boonstra, N, Nieman, D H, van den Berg, D P G, Linszen, D H, Wunderink, L, Veling, W, Smit, H F E & van der Gaag, M 2017, ' Four-Year Cost-effectiveness of Cognitive Behavior Therapy for Preventing First-episode Psychosis: The Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial. ', Schizophrenia Bulletin, vol. 43, no. 2, pp. 365-374 . https://doi.org/10.1093/schbul/sbw084 Schizophrenia Bulletin, 42(5), 1243-1252. Oxford University Press Schizophrenia bulletin, 43(2), 365-374. Oxford University Press |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbw084 |
| Popis: | Background: This study aims to evaluate the long-term cost-effectiveness of add-on cognitive behavior therapy (CBT) for the prevention of psychosis for individuals at ultrahigh risk (UHR) of psychosis.Method: The Dutch Early Detection and Intervention randomized controlled trial was used, comparing routine care (RC; n = 101) with routine care plus CBT for UHR (here called CBTuhr; n = 95). A cost-effectiveness analysis was conducted with treatment response (defined as proportion of averted transitions to psychosis) as an outcome and a cost-utility analysis with quality-adjusted life years (QALYs) gained as a secondary outcome.Results: The proportion of averted transitions to psychosis was significantly higher in the CBTuhr condition (with a risk difference of 0.122; b = 1.324, SEb = 0.017, z = 7.99, P < 0.001). CBTuhr showed an 83% probability of being more effective and less costly than RC by -US$ 5777 (savings) per participant. In addition, over the 4-year follow-up period, cumulative QALY health gains were marginally (but not significantly) higher in CBTuhr than for RC (2.63 vs. 2.46) and the CBTuhr intervention had a 75% probability of being the superior treatment (more QALY gains at lower costs) and a 92% probability of being cost-effective compared with RC at the Dutch threshold value (US$ 24 560; €20 000 per QALY).Conclusions: Add-on preventive CBTuhr had a high likelihood (83%) of resulting in more averted transitions to psychosis and lower costs as compared with RC. In addition, the intervention had a high likelihood (75%) of resulting in more QALY gains and lower costs as compared to RC. |
| Databáze: | OpenAIRE |
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