Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?
| Autor: | Daniel Antony Pass, Giulia Masetti, Duolao Wang, Julian R. Marchesi, Daryn Robert Michael, Timothy R. Hughes, Sue Plummer, T. S. Davies, Benjamin H. Mullish, A A Jack, Julie A. K. McDonald |
|---|---|
| Přispěvatelé: | Imperial College Healthcare NHS Trust- BRC Funding |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) obesity medicine.medical_specialty gut microbiome RC799-869 Overweight Biology Microbiology law.invention 03 medical and health sciences Probiotic qu_145.5 0302 clinical medicine Double-Blind Method law Weight loss gut-lung axis Internal medicine medicine wc_505 Humans Pandemics Respiratory Tract Infections Aged Respiratory tract infections qw_4 Probiotics Gastrointestinal Microbiome Gastroenterology Diseases of the digestive system. Gastroenterology Middle Aged medicine.disease Obesity Addendum Clinical trial 030104 developmental biology Infectious Diseases Upper respiratory tract infection upper respiratory tract infection 030211 gastroenterology & hepatology Self Report medicine.symptom 0605 Microbiology Research Article |
| Zdroj: | Gut Microbes article-version (VoR) Version of Record Gut Microbes, Vol 13, Iss 1 (2021) |
| ISSN: | 1949-0976 |
| Popis: | Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m2 experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|