Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution
| Autor: | Yasuhiro Shibasaki, Elisa Casadei, Yang Ding, Yong-Yao Yu, Fumio Takizawa, Zhen Xu, J. Oriol Sunyer, Thomas J. C. Sauters, Irene Salinas |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Immunoglobulins Inflammation Article Microbiology Evolution Molecular 03 medical and health sciences 0302 clinical medicine biology.animal medicine Animals Homeostasis Colonization Microbiome Pathogen Immunity Mucosal biology Microbiota Vertebrate General Medicine medicine.disease 030104 developmental biology Oncorhynchus mykiss biology.protein medicine.symptom Antibody Dysbiosis 030215 immunology |
| Zdroj: | Sci Immunol |
| Popis: | Although mammalian secretory immunoglobulin A (sIgA) targets mucosal pathogens for elimination, its interaction with the microbiota also enables commensal colonization and homeostasis. This paradoxical requirement in the control of pathogens versus microbiota raised the question of whether mucosal (secretory) Igs (sIgs) evolved primarily to protect mucosal surfaces from pathogens or to maintain microbiome homeostasis. To address this central question, we used a primitive vertebrate species (rainbow trout) in which we temporarily depleted its mucosal Ig (sIgT). Fish devoid of sIgT became highly susceptible to a mucosal parasite and failed to develop compensatory IgM responses against it. IgT depletion also induced a profound dysbiosis marked by the loss of sIgT-coated beneficial taxa, expansion of pathobionts, tissue damage, and inflammation. Restitution of sIgT levels in IgT-depleted fish led to a reversal of microbial translocation and tissue damage, as well as to restoration of microbiome homeostasis. Our findings indicate that specialization of sIgs in pathogen and microbiota control occurred concurrently early in evolution, thus revealing primordially conserved principles under which primitive and modern sIgs operate in the control of microbes at mucosal surfaces. |
| Databáze: | OpenAIRE |
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