Effects of crizotinib on creatinine clearance and renal hemodynamics
| Autor: | Wilbert M.T. Janssen, John W. G. van Putten, Lysbert Meijer-Schaap |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Cancer Research medicine.medical_specialty Lung Neoplasms Drug-Related Side Effects and Adverse Reactions medicine.medical_treatment Urology Renal function urologic and male genital diseases Kidney Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Crizotinib Carcinoma Non-Small-Cell Lung medicine Humans 030212 general & internal medicine Lung cancer Protein Kinase Inhibitors Neoplasm Staging Creatinine Chemotherapy business.industry Hemodynamics Effective renal plasma flow Middle Aged medicine.disease Filtration fraction Oncology chemistry 030220 oncology & carcinogenesis Female Kidney Diseases business medicine.drug Glomerular Filtration Rate |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 122 |
| ISSN: | 1872-8332 |
| Popis: | Objectives The tyrosine kinase inhibitor crizotinib may affect renal function. The mechanism of this effect is not understood. We aimed to get more insight by measuring renal hemodynamics in patients treated with crizotinib. Materials and methods Renal hemodynamics (i.e. glomerular filtration rate and effective renal plasma flow) were measured with radioactive tracers in three patients with stage IV non small-cell lung cancer during treatment with crizotinib. The results were compared with simultaneous creatinine based renal function measurements in the same patients. Results Patients had been treated with crizotinib between 155 and 320 days at the first measurement. In one patient the measurement was repeated after a total of one year and two months of treatment. All patients had been treated with chemotherapy containing cisplatin before. In these patients true glomerular filtration rate was 64–83% higher than estimated by creatinine based measurements. Filtration fraction, a measure of glomerular pressure, was increased in all three patients. The glomerular pressure was even further increased in a follow-up measurement. Conclusion Creatinine-based estimates of GFR on crizotinib may underestimate the true GFR. However, evidence of increased glomerular pressure may increase risk of long term true nephrotoxicity. |
| Databáze: | OpenAIRE |
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