Connecting the dots: combined control of endocytic recycling and degradation
| Autor: | Tobias Zech, Bryan Savage, Ewan MacDonald |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Endosome
Endocytic cycle Amino Acid Motifs Endocytic recycling Golgi Apparatus Endosomes Endocytosis Ligands Biochemistry Models Biological Organelles & Localization 03 medical and health sciences 0302 clinical medicine Lysosome medicine Animals Humans Phosphorylation Speaker Review endosome 030304 developmental biology Organelles 0303 health sciences Molecular Interactions Chemistry Ubiquitin Vesicle Cell Membrane Biological Transport Clathrin-Coated Vesicles endosomal sorting Signaling Clathrin Cell biology Actin Cytoskeleton Protein Transport medicine.anatomical_structure microfilaments Degradation (geology) ubiquitin signalling Pinocytosis Lysosomes 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Biochemical Society Transactions |
| ISSN: | 1470-8752 0300-5127 |
| Popis: | Endocytosis is an essential process where proteins and lipids are internalised from the plasma membrane in membrane-bound carriers, such as clathrin-coated vesicles. Once internalised into the cell these vesicles fuse with the endocytic network where their contents are sorted towards degradation in the lysosome or recycling to their origin. Initially, it was thought that cargo recycling is a passive process, but in recent years the identification and characterisation of specialised recycling complexes has established a hitherto unthought-of level of complexity that actively opposes degradation. This review will summarise recent developments regarding the composition and regulation of the recycling machineries and their relationship with the degradative pathways of the endosome. |
| Databáze: | OpenAIRE |
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