Contribution of immunohistochemistry toward the diagnosis of tumors of laboratory rats
| Autor: | Ch. Landes, A.L. Krinke, Georg Krinke, R. Hess, K. Heider, A.T. Mahrous |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adenoma medicine.drug_class Schwannoma Monoclonal antibody Antibodies Pathology and Forensic Medicine Diagnosis Differential Tubular adenoma medicine Carcinoma Animals Mesenchymoma Malignant Thymoma business.industry Calcium-Binding Proteins S100 Proteins Mesenchymal stem cell Mammary Neoplasms Experimental Rats Inbred Strains Neoplasms Experimental medicine.disease Immunohistochemistry Rats Female business |
| Zdroj: | Experimental Pathology. 40:239-250 |
| ISSN: | 0232-1513 |
| DOI: | 10.1016/s0232-1513(11)80308-7 |
| Popis: | A polyclonal antibody detecting S-100 protein (S-100) and a monoclonal antibody demonstrating epithelial cell (Lu-5) were used in addition to routine, hematoxylin-eosin stain to improve the identification of tumors of neural or epithelial origin diagnosed in conventionally treated tissue from rat bioassays. Among 108 lesions tested for S-100, 51 reacted positively; they included benign and malignant schwannoma, endomyocardial disease, some cases of benign and malignant thymoma, and renal tubular adenoma. S-100 protein is considered particularly useful for discriminating of neoplasms of Schwann cell origin from mesenchymal tumors. 31 of 51 lesions tested for Lu-5 reacted positively: they comprised adenoma, carcinoma, benign and malignant thymoma and atriocaval node tumor of the heart. Lu-5 was especially useful to distinguish epithelial from mesenchymal neoplasms and was capable of identifying epithelial elements in lymphocyte-rich thymomas as well as in dedifferentiated or autolytic tumors. The binding of both antibodies in neoplastic tissue was compared with a complete set of anatomically normal rat tissues. |
| Databáze: | OpenAIRE |
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