The prognostic significance of angina pectoris preceding the occurrence of a first acute myocardial infarction in 4166 consecutive hospitalized patients
| Autor: | Leonardo Reisin, Yehezkiel Kishon, Solomon Behar, Henrietta Reicher-Reiss, Jacob Barzilai, Edward Abinader, Abraham Palant, Yaacov Friedman, Jacob Agmon, Babeth Rabinovich, Izhar Zahavi, Monty Zion, Uri Goldbourt, Nissim Kauli, Zwi Schlesinger, Elieser Kaplinsky, Benyamin Peled |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Hospitalized patients Myocardial Infarction Angina Pectoris Cohort Studies Angina Internal medicine Prevalence Humans Medicine cardiovascular diseases Myocardial infarction Proportional Hazards Models business.industry Mortality rate Middle Aged Prognosis medicine.disease Survival Analysis Surgery Hospitalization Multivariate Analysis Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 123:1481-1486 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(92)90798-z |
| Popis: | We examined the role of chronic (greater than 1 month) angina pectoris (AP) before acute myocardial infarction (AMI) in predicting hospital and long-term mortality rates among 4166 patients with first AMIs. The prevalence of AP in these patients was 43%. Chronic AP was more common in women (49%), patients with hypertension (49%), and diabetic patients (49%) than in men and counterparts free of the former conditions (p less than 0.005). In patients with AP the hospital course was more complicated and non-Q-wave AMI was more common than in counterparts without AP. In-hospital (16%), as well as 1 (8%)- and 5-year postdischarge (26%), mortality rates in hospital survivors were higher among patients with previous AP than in patients without previous AP (12%, 6%, and 19%, respectively) (p less than 0.01). After adjustment for age and all other predictors of increased hospital mortality rates in this cohort of patients, AP preceding AMI emerged as an independent predictor of increased hospital mortality rates (odds ratio 1.30; 90% confidence interval 1.10 to 1.53). For postdischarge mortality rates (mean follow-up 5 1/2 years), the covariate-adjusted relative risk of death in patients with AP was similar at 1.29 (p less than 0.0001; 90% confidence interval 1.16 to 1.44), according to estimation by Cox proportional hazards model. These data support the notion that preexisting AP identifies a group of patients at increased risk of death. |
| Databáze: | OpenAIRE |
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