The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study
| Autor: | Larissa Correa Hermeto, Klebs Tavares de Assis, Rafael de Rossi, Lucas Latta Escobar, Pedro Santana de Camargo, Natalia de Andrade Bicudo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
RD1-811 Respiratory rate 040301 veterinary sciences Ovariectomy Analgesic Pain Hysterectomy Dexamethasone 0403 veterinary science 03 medical and health sciences Acepromazine 0302 clinical medicine Dogs 030202 anesthesiology Heart rate medicine Animals General anaesthesia Pain Measurement Analgesics Pain Postoperative Dose-Response Relationship Drug business.industry Lidocaine 04 agricultural and veterinary sciences Lignocaine Epidural space Surgery Analgesia Epidural medicine.anatomical_structure Anesthesia Female Propofol business medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.32 n.4 2017 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 32, Issue: 4, Pages: 307-318, Published: APR 2017 Acta Cirurgica Brasileira, Vol 32, Iss 4, Pp 307-318 (2017) |
| ISSN: | 1678-2674 |
| Popis: | Purpose: To evaluate the postoperative analgesic and adverse effects of three doses of dexamethasone, administered epidurally in combination with lignocaine, in dogs undergoing ovariohysterectomy (OVH). Methods: Twenty-four female dogs undergoing ovariohysterectomy were pre-medicated with acepromazine and general anaesthesia was induced and maintained with propofol. Animals were randomly allocated into four groups of six. The control group was given lignocaine 2% (LI) and the treatment groups were given lignocaine with either 2 mg dexamethasone (LIDEX2), 4 mg dexamethasone (LIDEX4) or 8 mg dexamethasone (LIDEX8) administered at the lumbosacral epidural space. Duration of postoperative analgesia, first analgesic rescue, motor blockade, heart rate, blood pressure, respiratory rate, and rectal temperature were evaluated. Results: The duration of postoperative analgesia was 19.5 (SD 6) hours for LIDEX8 (p=0.001), 10 (SD 2) hours for LIDEX4 (p=0.002), 4 (SD 2) hours for LIDEX2 (p=0.074) treatments compared with values for the LI control treatment 2.2 (SD 1.6) hours. All treatments had significant cardiovascular and respiratory alterations but they were within acceptable range in these clinically healthy female dogs. Conclusion: Dexamethasone added to epidural lignocaine significantly extends the postoperative analgesia after ovariohysterectomy in female dogs. |
| Databáze: | OpenAIRE |
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