A high sodium intake reduces antiproteinuric response to renin–angiotensin–aldosterone system blockade in kidney transplant recipients
| Autor: | Gema Fernández-Fresnedo, Lara Belmar, Juan Carlos Ruiz San Millán, Cristina Sango, Fozi Moussa, Emilio Rodrigo, Celestino Piñera, Manuel Arias, Elena Monfá |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology Urology 030230 surgery lcsh:RC870-923 urologic and male genital diseases Kidney transplant Kidney transplantation Angiotensin 03 medical and health sciences 0302 clinical medicine Internal medicine Renin medicine Angiotensin-converting-enzyme inhibitor cardiovascular diseases Salt intake Proteinuria urogenital system business.industry Patient survival lcsh:Diseases of the genitourinary system. Urology female genital diseases and pregnancy complications surgical procedures operative Endocrinology Nephrology Angiotensin II receptor blocker medicine.symptom business |
| Zdroj: | Nefrología (English Edition), Vol 36, Iss 5, Pp 545-551 (2016) |
| ISSN: | 2013-2514 |
| DOI: | 10.1016/j.nefroe.2016.01.011 |
| Popis: | Background: Post-transplant proteinuria is associated with lower graft and patient survival. Renin–angiotensin–aldosterone system blockers are used to reduce proteinuria and improve renal outcome. Although it is known that a high salt intake blunts the antiproteinuric effect of ACEI and ARB drugs in non-transplant patients, this effect has not been studied in kidney transplant recipients. Objective: To analyse the relationship between sodium intake and the antiproteinuric effect of ACEI/ARB drugs in kidney transplant recipients. Methods: We selected 103 kidney transplant recipients receiving ACEI/ARB drugs for more than 6 months due to proteinuria >1 g/day. Proteinuria was analysed at baseline and at 6 months after starting ACEI/ARB treatment. Salt intake was estimated by urinary sodium to creatinine ratio (uNa/Cr). Results: Proteinuria fell to less than 1 g/day in 46 patients (44.7%). High uNa/Cr was associated with a smaller proteinuria decrease (r = −0.251, p = 0.011). The percentage of proteinuria reduction was significantly lower in patients in the highest uNa/Cr tertile [63.9% (IQR 47.1%), 60.1% (IQR 55.4%), 38.9% (IQR 85.5%), p = 0.047]. High uNa/Cr independently relates (OR 2.406 per 100 mEq/g, 95% CI: 1.008–5.745, p = 0.048) to an antiproteinuric response |
| Databáze: | OpenAIRE |
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