Visualization and prediction of porosity in roller compacted ribbons with near-infrared chemical imaging (NIR-CI)
| Autor: | P. Olsen, Milad Khorasani, José Manuel Amigo, Jukka Rantanen, Jørn M. Sonnergaard, Poul Bertelsen |
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| Rok vydání: | 2015 |
| Předmět: |
Chemical imaging
Chemistry Pharmaceutical Drug Compounding Clinical Biochemistry Compaction Pharmaceutical Science Analytical Chemistry Excipients Drug Discovery Ribbon Pressure Composite material Cellulose Porosity Spectroscopy Principal Component Analysis Spectroscopy Near-Infrared Chemistry Near-infrared spectroscopy Mercury Monitoring and control Visualization Mercury intrusion Powders Oils |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 109:11-17 |
| ISSN: | 0731-7085 |
| Popis: | The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R(2)=0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring and control of continuously operating roller compaction line. |
| Databáze: | OpenAIRE |
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