Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
| Autor: | L. Pašková, Ladislav Habala, Jindra Valentová, František Bilka, B. Oboňová, Andrea Bilková |
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| Rok vydání: | 2021 |
| Předmět: |
010405 organic chemistry
Chemistry amphiphilic compounds Agaric acid RM1-950 anticancer 010402 general chemistry Antimicrobial 01 natural sciences agaric acid 0104 chemical sciences bioinorganic chemistry Transition metal metallodrugs antimicrobial Therapeutics. Pharmacology General Pharmacology Toxicology and Pharmaceutics Cytotoxicity Nuclear chemistry |
| Zdroj: | European Pharmaceutical Journal, Vol 68, Iss 1, Pp 46-53 (2021) |
| ISSN: | 2453-6725 |
| DOI: | 10.2478/afpuc-2020-0018 |
| Popis: | Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes. |
| Databáze: | OpenAIRE |
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