A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balance
| Autor: | Lynn M. Thomson, Peter McCaffery, Peter J. Morgan, Alexander W. Ross, Claus D. Mayer, Patrick N. Stoney, Gisela Helfer |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Thyroid Hormones Chemokine medicine.medical_specialty Photoperiod Ependymoglial Cells Hypothalamus Retinoic acid Inflammation Article Rats Sprague-Dawley Eating Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ependyma Internal medicine medicine Animals Humans Chemerin Receptor Injections Intraventricular 2. Zero hunger Neuronal Plasticity Multidisciplinary biology Body Weight Rats Inbred F344 Rats 030104 developmental biology Endocrinology chemistry biology.protein Intercellular Signaling Peptides and Proteins Receptors Chemokine Chemokines medicine.symptom Signal transduction Energy Metabolism 030217 neurology & neurosurgery Signal Transduction Hormone |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep26830 |
| Popis: | Long-term and reversible changes in body weight are typical of seasonal animals. Thyroid hormone (TH) and retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have been implicated in the photoperiodic response. We investigated signalling downstream of RA and how this links to the control of body weight and food intake in photoperiodic F344 rats. Chemerin, an inflammatory chemokine, with a known role in energy metabolism, was identified as a target of RA. Gene expression of chemerin (Rarres2) and its receptors were localised within the tanycytes and ependymal cells, with higher expression under long (LD) versus short (SD) photoperiod, pointing to a physiological role. The SD to LD transition (increased food intake) was mimicked by 2 weeks of ICV infusion of chemerin into rats. Chemerin also increased expression of the cytoskeletal protein vimentin, implicating hypothalamic remodelling in this response. By contrast, acute ICV bolus injection of chemerin on a 12 h:12 h photoperiod inhibited food intake and decreased body weight with associated changes in hypothalamic neuropeptides involved in growth and feeding after 24 hr. We describe the hypothalamic ventricular zone as a key site of neuroendocrine regulation, where the inflammatory signal, chemerin, links TH and RA signaling to hypothalamic remodeling. |
| Databáze: | OpenAIRE |
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