Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions

Autor: Gere S. diZerega, Holly Maulhardt, Alyson Marin, Holly Hesseltine
Rok vydání: 2021
Předmět:
0301 basic medicine
Cancer Research
Lung Neoplasms
medicine.medical_treatment
Docetaxel
Injections
Intralesional
T-Lymphocytes
Regulatory
Gastroenterology
Metastasis
NanoDoce
Mice
Breast cancer
0302 clinical medicine
CTLA-4 Antigen
Immune Checkpoint Inhibitors
Mice
Inbred BALB C
Hematology
Antibodies
Monoclonal
General Medicine
Natural killer T cell
Combined Modality Therapy
Primary tumor
Tumor Burden
Killer Cells
Natural
Oncology
030220 oncology & carcinogenesis
Female
Immunotherapy
medicine.drug
medicine.medical_specialty
Anti-mCTLA-4
Antineoplastic Agents
Mammary Neoplasms
Animal
03 medical and health sciences
Lymphocytes
Tumor-Infiltrating
Immune system
Internal medicine
medicine
Animals
Bioluminescence imaging
LSAM-DTX
Particle Size
Original Paper
business.industry
Myeloid-Derived Suppressor Cells
medicine.disease
030104 developmental biology
business
Zdroj: Medical Oncology (Northwood, London, England)
ISSN: 1559-131X
1357-0560
Popis: We describe here characterization of the response of local and metastatic disease and immunomodulation following intratumoral (IT) injection of submicron particle docetaxel (SPD) administered alone or in combination with systemic antibody anti-mCTLA-4 (anti-mCTLA-4) in the metastatic 4T1-Luc2-1A4 (4T1) murine breast cancer model. In-life assessments of treatment tolerance, tumor volume (TV), and metastasis were performed (n = 10 animals/group). At study end, immune cell populations in tumor-site tissues and peripheral blood were analyzed using flow cytometry. Signs of distress typical of this aggressive tumor model occurred across all animals except for the combination treated which were asymptomatic and gained weight. TV at study end was significantly reduced in the combination group versus untreated [43% reduced (p p p p p p p p p
Databáze: OpenAIRE
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