Cellular senescence and chronological age in various human tissues
| Autor: | Theo Stijnen, Rudi G. J. Westendorp, Monique S. Slee-Valentijn, Andrea B. Maier, Mariette E. C. Waaijer, Camilla S. L. Tuttle |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Senescence Aging Health (social science) Reviews Cellular senescence Physiology Cell Cycle Proteins Computational biology Review Biology Health Professions (miscellaneous) Abstracts 03 medical and health sciences Text mining 0302 clinical medicine cellular senescence Animals Humans human Life-span and Life-course Studies Cell Proliferation immunosenescence business.industry aging Cell Biology Chronological age Immunosenescence 030104 developmental biology Tissue sections Chronic disease Organ Specificity Meta-analysis Tissue type business cell cycle proteins Biomarkers Software 030217 neurology & neurosurgery DNA Damage |
| Zdroj: | Aging Cell Tuttle, C S L, Waaijer, M E C, Slee-Valentijn, M S, Stijnen, T, Westendorp, R & Maier, A B 2020, ' Cellular senescence and chronological age in various human tissues : A systematic review and meta-analysis ', Aging Cell, vol. 19, no. 2, e13083 . https://doi.org/10.1111/acel.13083 Tuttle, C S L, Waaijer, M E C, Slee-Valentijn, M S, Stijnen, T, Westendorp, R & Maier, A B 2020, ' Cellular senescence and chronological age in various human tissues : A systematic review and meta-analysis ', Aging Cell, vol. 19, no. 2, e13083, pp. e13083 . https://doi.org/10.1111/acel.13083 |
| ISSN: | 1474-9718 |
| DOI: | 10.1111/acel.13083 |
| Popis: | Senescent cells in tissues and organs are considered to be pivotal to not only the aging process but also the onset of chronic disease. Accumulating evidence from animal experiments indicates that the magnitude of senescence can vary within and between aged tissue samples from the same animal. However, whether this variation in senescence translates across to human tissue samples is unknown. To address this fundamental question, we have conducted a systematic review and meta‐analysis of all available literature investigating the magnitude of senescence and its association with chronological age in human tissue samples. While senescence is higher in aged tissue samples, the magnitude of senescence varies considerably depending upon tissue type, tissue section, and marker used to detect senescence. These findings echo animal experiments demonstrating that senescence levels may vary between organs within the same animal. Senescence load in human tissues is associated with chronological age, but heterogeneous between human tissues. |
| Databáze: | OpenAIRE |
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