Urea incorporated into ordered mesoporous silica for potential cosmetic application
| Autor: | T.S. Martins, Heron Dominguez Torres da Silva, Vânia Rodrigues Leite-Silva, Celio Takashi Higuchi, Marcelo Dutra Duque, Camila Vieira da Silva, Patricia Santos Lopes, Newton Andréo-Filho |
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| Rok vydání: | 2020 |
| Předmět: |
Transepidermal water loss
Cosmetic active Mesoporous silica Post-synthesis law.invention Tetraethyl orthosilicate RS1-441 SBA-15 chemistry.chemical_compound Pharmacy and materia medica Physisorption Chemical engineering chemistry law Urea Calcination Mesoporous material Incipient wetness impregnation |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020) |
| ISSN: | 2175-9790 |
| DOI: | 10.1590/s2175-97902020000317560 |
| Popis: | Urea’s thermal instability and burning on sensitive skin can cause problems for cosmetic formulations. To overcome these drawbacks, urea was incorporated into ordered mesoporous silica (SBA-15). SBA-15 was synthesized using tetraethyl orthosilicate and Pluronic® P123 in an acid medium. Urea (20 wt.%) was incorporated into calcined SBA-15 by the incipient wetness impregnation method. Several techniques were used to characterize the samples. Skin hydration and transepidermal water loss were measured using Corneometer® CM 825 PC and Tewameter® 300 TM. Results showed that the structural properties of SBA-15Urea were similar to pure SBA-15, indicating that SBA-15 remained structured even after urea incorporation. Nitrogen physisorption data showed the volume and surface area of the pores in SBA-15Urea were much lower than those in SBA-15, demonstrating that urea was deposited inside the mesopores. In vivo moisturization studies revealed that SBA-15Urea was not able to reduce transepidermal water loss compared to the other products and control, while forming a non-occlusive surface film on the skin. We conclude that incorporation of urea in the pores of the inorganic SBA-15 matrix is a promising approach to enhancing its stability and providing a prolonged moisturizing effect. |
| Databáze: | OpenAIRE |
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