Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders
| Autor: | Md. Jakaria, Jamil Ahmad, Lotfi Aleya, Abdullah Al Mamun, Md. Ataur Rahman, S. Thangapandiyan, Mohamed M. Abdel-Daim, Bijo Mathew, Md. Sahab Uddin |
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| Přispěvatelé: | Department of Pharmacy, Southeast University, Dhaka, Bangladesh, Department of Zoology, Bharathiar University, Tamil Nadu, India, Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India, Department of Pharmacology, Suez Canal University, Ismailia, Egyp, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences NF-E2-Related Factor 2 Excitotoxicity 010501 environmental sciences medicine.disease_cause 01 natural sciences Neuroprotection Nrf2 activation chemistry.chemical_compound Isothiocyanates Detoxification medicine Humans Environmental Chemistry Waste Management and Disposal Neuroinflammation ComputingMilieux_MISCELLANEOUS 0105 earth and related environmental sciences business.industry Pollution [SDE.ES]Environmental Sciences/Environmental and Society 3. Good health Oxidative Stress chemistry Sulfoxides Nervous System Diseases business Neuroscience Oxidative stress Signal Transduction Nrf2 signaling Sulforaphane |
| Zdroj: | Science of the Total Environment Science of the Total Environment, Elsevier, 2020, 707, pp.135624. ⟨10.1016/j.scitotenv.2019.135624⟩ |
| ISSN: | 0048-9697 1879-1026 |
| DOI: | 10.1016/j.scitotenv.2019.135624⟩ |
| Popis: | Neurological disorders represent a great challenge and are the leading cause of death and disability globally. Although numerous complicated mechanisms are involved in the progressions of chronic and acute neurodegenerative disorders, most of the diseases share mutual pathogenic features such as oxidative stress, mitochondrial dysfunction, neuroinflammation, protein misfolding, excitotoxicity, and neuronal damage, all of these are the common targets of nuclear factor erythroid 2 related factor 2 (Nrf2) signaling cascade. No cure has yet been discovered to tackle these disorders, so, intervention approaches targeting phytochemicals have been recommended as an alternative form of treatment. Sulforaphane is a sulfur-rich dietary phytochemical which has several activities such as antioxidant, anti-inflammatory, and anti-tumor via multiple targets and various mechanisms. Given its numerous actions, sulforaphane has drawn considerable attention for neurological disorders in recent years. Nrf2 is one of the most crucial targets of sulforaphane which has potential in regulating the series of cytoprotective enzyme expressions that have neuroprotective, antioxidative, and detoxification actions. Neurological disorders are auspicious candidates for Nrf2-targeted treatment strategy. Sulforaphane protects various neurological disorders by regulating the Nrf2 pathway. In this article, we recapitulate current studies of sulforaphane-mediated Nrf2 activation in the treatment of various neurological disorders. |
| Databáze: | OpenAIRE |
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