Air or oxygen as driving gas for nebulised salbutamol
| Autor: | S Green, J F Price, J G Gleeson |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.drug_class Partial Pressure Compressed air chemistry.chemical_element Oxygen Random Allocation Bronchodilator medicine Humans Albuterol Child Hypoxia Asthma Clinical Trials as Topic business.industry Air Nebulizers and Vaporizers Hypoxia (environmental) Oxygen–haemoglobin dissociation curve Partial pressure medicine.disease chemistry Child Preschool Anesthesia Acute Disease Pediatrics Perinatology and Child Health Salbutamol Female business Research Article medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 63:900-904 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.63.8.900 |
| Popis: | The effects of nebulised salbutamol driven by compressed air or oxygen were compared in a randomised crossover study during 27 attacks of acute asthma. Arterial oxygen saturation fell by 2-6% during or after treatment in 10 cases: seven with compressed air, two with oxygen, and one with both driving gases. Hypoxaemia occurred in younger children and in those who fell asleep, but was not related to the level of arterial oxygen saturation before treatment or the size of the response to bronchodilator therapy. More children fell asleep with compressed air nebulisation. Arterial oxygen saturation improved and heart rates remained stable during treatment when oxygen was the driving gas. After treatment, however, arterial oxygen saturation fell and heart rates rose to values that were similar to those after treatment with compressed air. The falls in arterial oxygen saturation we observed, though comparatively small, would be clinically important on the steep part of the oxygen dissociation curve, and our results emphasise that families with home nebulisers should seek medical advice early when their children develop severe asthma. The benefits of using oxygen as the driving gas during nebulisation were transient, and in severe asthma treatment with oxygen needs to be continued after the nebulised salbutamol has been given. |
| Databáze: | OpenAIRE |
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