Yellow fever transmission in non-human primates, Bahia, Northeastern Brazil
| Autor: | Leandro Ferraz Oliveira Santos, Alessandro Pecego Martins Romano, Jaqueline Goes de Jesus, Allison Fabri, Vagner Fonseca, Joilson Xavier, Mirza de Carvalho Santana Cordeiro, Roberto Fonseca dos Santos, Adeilde do Socorro Guedes, Neuza Santos de Jesus Silva, Arabela Leal e Silva de Mello, Sintia Sacramento Cerqueira Torquato, Jeane Magnavita da Fonseca Cerqueira, Pedro Macedo da Silva Filho, André Luiz de Abreu, Ademilson Brás Alves, Rosemary Sarmento Oitiçica Dourado, Julien Thézé, Maricelia Lima Maia, Felicidade Mota Pereira, Marta Giovanetti, Nuno R. Faria, Maria Angélica Mares-Guia, Ana Maria Bispo de Filippis, Luciana Reboredo de Oliveira da Silva, Tiago Gräf, Leandro Abade, Zuinara Pereira Gusmão Maia, Carlos F. Campelo de Albuquerque, Julio Croda, Rodrigo Fabiano do Carmo Said, Eloisa Bahia Santana, Gabriel Muricy Cunha, Jananci Xavier Gomes Cerqueira, Luiz Carlos Junior Alcantara |
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| Přispěvatelé: | Instituto Gonçalo Moniz, Partenaires INRAE, Department of Infectious Diseases, Istituto Superiore di Sanita [Rome], Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Universidade Federal de Minas Gerais, Department of Zoology, University of Oxford [Oxford], Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Coordenação Geral de Vigilância de Arboviroses (CGARB), Wellcome Trust, Medical Research Council-São Paulo Research Foundation (FAPESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epidemiology [SDV]Life Sciences [q-bio] RC955-962 Disease Vectors Mosquitoes Geographical locations Animal Diseases 0302 clinical medicine Medical Conditions Arctic medicine. Tropical medicine Genotype Medicine and Health Sciences Alouatta 11 Medical and Health Sciences Phylogeny Data Management Mammals Mammalian Genomics Phylogenetic tree Transmission (medicine) Yellow fever Eukaryota Callithrix Phylogenetic Analysis Genomics 3. Good health Phylogenetics Insects Infectious Diseases Vertebrates Public aspects of medicine RA1-1270 Yellow fever virus Brazil Research Article Primates medicine.medical_specialty Computer and Information Sciences Infectious Disease Control Arthropoda 030231 tropical medicine Genome Viral Biology Disease Surveillance Epizootics 03 medical and health sciences Tropical Medicine Yellow Fever medicine Genetics Animals Humans Evolutionary Systematics Epizootic Ecosystem Taxonomy Evolutionary Biology Molecular epidemiology Public Health Environmental and Occupational Health Primate Diseases Organisms Outbreak Biology and Life Sciences 06 Biological Sciences South America medicine.disease Virology Invertebrates Insect Vectors Species Interactions 030104 developmental biology Animal Genomics Infectious Disease Surveillance Amniotes People and places Zoology Entomology |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (8), pp.e0008405. ⟨10.1371/journal.pntd.0008405⟩ PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008405 (2020) |
| ISSN: | 1935-2727 1935-2735 |
| DOI: | 10.1371/journal.pntd.0008405⟩ |
| Popis: | Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP. Among affected areas, Bahia state in Northeastern was the only region with no autochthonous human cases. By using next generation sequence approach, we investigated the molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented human cases. We investigated 47 YFV positive tissue samples from NHP cases to generate 8 novel YFV genomes. ML phylogenetic tree reconstructions and automated subtyping tools placed the newly generated genomes within the South American genotype I (SA I). Our analysis revealed that the YFV genomes from Bahia formed two distinct well-supported phylogenetic clusters that emerged most likely of an introduction from Minas Gerais and Espírito Santo states. Vegetation coverage analysis performed shows predominantly low to medium vegetation coverage in Bahia state. Together, our findings support the hypothesis of two independent YFV SA-I introductions. We also highlighted the effectiveness of the actions taken by epidemiological surveillance team of the state to prevented human cases. Author summary Between 2016 and 2018, Brazil witnessed the largest YFV outbreak since years, with 2.154 cases and 745 deaths. Here we report the introduction of the virus in the state of Bahia suggesting two independent introductions from Minas Gerais and Espirito Santo. We also highlight the actions taken by epidemiological surveillance division that may have prevent human infections. |
| Databáze: | OpenAIRE |
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