Inducible Intracellular Membranes: Molecular Aspects and Emerging Applications
| Autor: | Christophe Tribet, Jorge Royes, Valérie Biou, Bruno Miroux, Nathalie Dautin |
|---|---|
| Přispěvatelé: | Laboratoire de biologie physico-chimique des protéines membranaires (LBPC-PM (UMR_7099)), Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640) (PASTEUR), Département de Chimie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Lipid biosynthesis Protein Conformation [SDV]Life Sciences [q-bio] lcsh:QR1-502 Bioengineering Review Membrane curvature 01 natural sciences Applied Microbiology and Biotechnology lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound 010608 biotechnology Cardiolipin Inner membrane Phospholipids 030304 developmental biology Organelles 0303 health sciences Membrane biosynthesis Cell Membrane microbiology Membrane Proteins Membrane remodeling Cell biology Membrane chemistry Membrane protein Membrane biogenesis Cell Surface Extensions Intracellular Biotechnology |
| Zdroj: | Microbial Cell Factories Microbial Cell Factories, BioMed Central, 2020, 19 (1), pp.176. ⟨10.1186/s12934-020-01433-x⟩ Microbial Cell Factories, Vol 19, Iss 1, Pp 1-26 (2020) |
| ISSN: | 1475-2859 |
| DOI: | 10.1186/s12934-020-01433-x⟩ |
| Popis: | Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de novo phospholipid biosynthesis and modulation of membrane morphology. Interestingly, the overproduction of certain membrane proteins hijack these regulation networks, leading to the formation of impressive intracellular membrane structures in both prokaryotic and eukaryotic cells. The proteins triggering an abnormal accumulation of membrane structures inside the cells (or membrane proliferation) share two major common features: (1) they promote the formation of highly curved membrane domains and (2) they lead to an enrichment in anionic, cone-shaped phospholipids (cardiolipin or phosphatidic acid) in the newly formed membranes. Taking into account the available examples of membrane proliferation upon protein overproduction, together with the latest biochemical, biophysical and structural data, we explore the relationship between protein synthesis and membrane biogenesis. We propose a mechanism for the formation of these non-physiological intracellular membranes that shares similarities with natural inner membrane structures found in α-proteobacteria, mitochondria and some viruses-infected cells, pointing towards a conserved feature through evolution. We hope that the information discussed in this review will give a better grasp of the biophysical mechanisms behind physiological and induced intracellular membrane proliferation, and inspire new applications, either for academia (high-yield membrane protein production and nanovesicle production) or industry (biofuel production and vaccine preparation). |
| Databáze: | OpenAIRE |
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