Chiral PEDOT-Based Enantioselective Electrode Modification Material for Chiral Electrochemical Sensing: Mechanism and Model of Chiral Recognition
| Autor: | Liqi Dong, Xiaofei Zhu, Hui Sun, Xuemin Duan, Jingkun Xu, Youshan Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Aqueous solution
Chemistry Enantioselective synthesis 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Electrochemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Analytical Chemistry Stereospecificity PEDOT:PSS Polymerization Electrode Organic chemistry Enantiomer 0210 nano-technology |
| Zdroj: | Analytical Chemistry. 89:9695-9702 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/acs.analchem.7b01095 |
| Popis: | The development of electrochemical methods for enantioselective recognition is a focus of research in pharmaceuticals and biotechnology. In this study, a pair of water-soluble chiral 3,4-ethylenedioxythiophene (EDOT) derivatives, (R)-2′-hydroxymethyl-3,4-ethylenedioxythiophene ((R)-EDTM) and (S)-2′-hydroxymethyl-3,4-ethylenedioxythiophene ((S)-EDTM), were synthesized and electrodeposited on the surface of a glassy carbon electrode (GCE) via current–time (I–t) polymerization in an aqueous LiClO4 electrolyte. These chiral PEDOT polymers were used to fabricate chiral sensors and to investigate the enantioselective recognition of d-/l-3,4-dihydroxyphenylalanine, d-/l-tryptophan, and (R)-/(S)-propranolol enantiomers, respectively. The results indicated that the (R)-PEDTM/GCE sensor showed a higher peak current response toward the levo or (S) forms of the tested enantiomers, while the opposite phenomenon occurred for (S)-PEDTM/GCE. The mechanism of the stereospecific interaction between these enantiomers and th... |
| Databáze: | OpenAIRE |
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