Pleuroparenchymal fibroelastosis in idiopathic pulmonary fibrosis: Survival analysis using visual and computer-based computed tomography assessment

Autor: Recep Savaş, Iain A. Stewart, Omer Unat, Marcel Veltkamp, Eyjolfur Gudmundsson, Hendrik W. van Es, Coline H.M. van Moorsel, Mark Jones, Frouke T. van Beek, An Zhao, Christopher J. Brereton, Arjun Nair, Athol U. Wells, Katarina Pontoppidan, Joseph Jacob, Daniel C. Alexander, Nesrin Mogulkoc, Bahareh Gholipour, Sam M. Janes
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: EClinicalMedicine, Vol 38, Iss, Pp 101009-(2021)
EClinicalMedicine
Popis: Background: Idiopathic pulmonary fibrosis (IPF) and pleuroparenchymal fibroelastosis (PPFE) are known to have poor outcomes but detailed examinations of prognostic significance of an association between these morphologic processes are lacking. Methods: Retrospective observational study of independent derivation and validation cohorts of IPF populations. Upper-lobe PPFE extent was scored visually (vPPFE) as categories of absent, moderate, marked. Computerised upper-zone PPFE extent (cPPFE) was examined continuously and using a threshold of 2.5% pleural surface area. vPPFE and cPPFE were evaluated against 1-year FVC decline (estimated using mixed-effects models) and mortality. Multivariable models were adjusted for age, gender, smoking history, antifibrotic treatment and diffusion capacity for carbon monoxide. Findings: PPFE prevalence was 49% (derivation cohort, n = 142) and 72% (validation cohort, n = 145). vPPFE marginally contributed 3-14% to variance in interstitial lung disease (ILD) severity across both cohorts. In multivariable models, marked vPPFE was independently associated with 1-year FVC decline (derivation: regression coefficient 18.3, 95 CI 8.47-28.2%; validation: 7.51, 1.85-13.2%) and mortality (derivation: hazard ratio [HR] 7.70, 95% CI 3.50-16.9; validation: HR 3.01, 1.33-6.81). Similarly, continuous and dichotomised cPPFE were associated with 1-year FVC decline and mortality (cPPFE > 2.5% derivation: HR 5.26, 3.00-9.22; validation: HR 2.06, 1.28-3.31). Individuals with cPPFE > 2.5% or marked vPPFE had the lowest median survival, the cPPFE threshold demonstrated greater discrimination of poor outcomes at two and three years than marked vPPFE. Interpretation: PPFE quantification supports distinction of IPF patients with a worse outcome independent of established ILD severity measures. This has the potential to improve prognostic management and elucidate separate pathways of disease progression. Funding: This research was funded in whole or in part by the Wellcome Trust [209,553/Z/17/Z] and the NIHR UCLH Biomedical Research Centre, UK. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Wellcome Trust [209553/Z/17/Z]; NIHR UCLH Biomedical Research Centre, UK; NIHR South-ampton Biomedical Research Centre; EPSRC [EP/M020533/1]
This research was funded in whole or in part by the Wellcome Trust [209553/Z/17/Z]. For the purpose of open access, the author has applied a CC-BY public copyright licence to any author accepted manuscript version arising from this submission. This project, JJ, EG and SMJ were also supported by the NIHR UCLH Biomedical Research Centre, UK. MGJ and CB acknowledge the support of the NIHR South-ampton Biomedical Research Centre. EPSRC grant EP/M020533/1 helped support this work.
Databáze: OpenAIRE
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