Childhood risk factors and carotid atherosclerotic plaque in adulthood: The Cardiovascular Risk in Young Finns Study
| Autor: | Päivi Tossavainen, Nina Hutri-Kähönen, Markus Juonala, Eero Jokinen, Mika Kähönen, Jorma Viikari, Costan G. Magnussen, Olli T. Raitakari, Jaakko Nevalainen, Ville Kytö, Terho Lehtimäki, Tomi Laitinen, Juhani S. Koskinen |
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| Přispěvatelé: | Children's Hospital, Lastentautien yksikkö, HUS Children and Adolescents |
| Rok vydání: | 2020 |
| Předmět: |
Carotid Artery Diseases
Male 0301 basic medicine Blood Pressure CHILDREN PROGRESSION DETERMINANTS 030204 cardiovascular system & hematology Carotid Intima-Media Thickness INTIMA-MEDIA THICKNESS 0302 clinical medicine Medicine Area under the curve - Childhood risk factor long-term burden Family history Child Finland Ultrasonography Area under the curve – Childhood risk factor long-term burden Incidence Area under the curve ASSOCIATION Plaque Atherosclerotic 3142 Public health care science environmental and occupational health Carotid atherosclerotic plaque PREVALENCE 3. Good health Carotid Arteries Cardiovascular risk factor cut-offs DENSITY-LIPOPROTEIN CHOLESTEROL Cardiovascular Diseases Child Preschool Disease Progression Female ADIPOSITY Cardiology and Cardiovascular Medicine CORONARY-ARTERY CALCIFICATION medicine.medical_specialty Adolescent Cardiovascular risk factors Lumen (anatomy) 03 medical and health sciences Internal medicine Humans Childhood cardiovascular risk factors business.industry Guideline Atherosclerosis medicine.disease Coronary heart disease 030104 developmental biology Heart Disease Risk Factors 3121 General medicine internal medicine and other clinical medicine Relative risk COHORT PROFILE business Dyslipidemia |
| Zdroj: | Atherosclerosis. 293:18-25 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2019.11.029 |
| Popis: | Background and aims Carotid plaque is a specific sign of atherosclerosis and adults with carotid plaque are at increased risk for cardiovascular outcomes. Atherosclerosis has roots in childhood and pediatric guidelines provide cut-off values for cardiovascular risk factors. However, it is unknown whether these cut-offs predict adulthood advanced atherosclerosis. Methods The Cardiovascular Risk in Young Finns Study is a follow-up of children that begun in 1980 when 2653 participants with data for the present analyses were aged 3–18 years. In 2001 and 2007 follow-ups, in addition to adulthood cardiovascular risk factors, carotid ultrasound data was collected. Long-term burden, as the area under the curve, was evaluated for childhood (6–18 years) risk factors. To study the associations of guideline-based cut-offs with carotid plaque, both childhood and adult risk factors were classified according to clinical practice guidelines. Results Carotid plaque, defined as a focal structure of the arterial wall protruding into lumen >50% compared to adjacent intima-media thickness, was present in 88 (3.3%) participants. Relative risk for carotid plaque, when adjusted for age and sex, was 3.03 (95% CI, 1.76–5.21) for childhood dyslipidemia, 1.51 (95% CI, 0.99–2.32) for childhood elevated systolic blood pressure, and 1.93 (95% CI, 1.26–2.94) for childhood smoking. Childhood dyslipidemia and smoking remained independent predictors of carotid plaque in models additionally adjusted for adult risk factors and family history of coronary heart disease. Carotid plaque was present in less than 1% of adults with no childhood risk factors. Conclusions Findings reinforce childhood prevention efforts and demonstrate the utility of guideline-based cut-offs in identifying children at increased risk for adulthood atherosclerosis. |
| Databáze: | OpenAIRE |
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