Experience-Dependent Intrinsic Plasticity During Auditory Learning
| Autor: | Frank Johnson, Wei Wu, Richard Bertram, Richard L. Hyson, Matthew T. Ross, Diana Flores |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Nervous system Echoic memory Auditory learning education Nonsynaptic plasticity Biology Basal Ganglia Ion Channels Membrane Potentials Calcium Channels T-Type Mice 03 medical and health sciences 0302 clinical medicine Basal ganglia Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels medicine Animals Learning Zebra finch Research Articles Cerebral Cortex Neuronal Plasticity General Neuroscience 030104 developmental biology medicine.anatomical_structure nervous system Synaptic plasticity Auditory Perception behavior and behavior mechanisms Vocal learning Finches Vocalization Animal Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Neuroscience. 39:1206-1221 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1036-18.2018 |
| Popis: | Song learning in zebra finches (Taeniopygia guttata) requires exposure to the song of a tutor, resulting in an auditory memory. This memory is the foundation for later sensorimotor learning, resulting in the production of a copy of the tutor's song. The cortical premotor nucleus HVC (proper name) is necessary for auditory and sensorimotor learning as well as the eventual production of adult song. We recently discovered that the intrinsic physiology of HVC neurons changes across stages of song learning, but are those changes the result of learning or are they experience-independent developmental changes? To test the role of auditory experience in driving intrinsic changes, patch-clamp experiments were performed comparing HVC neurons in juvenile birds with varying amounts of tutor exposure. The intrinsic physiology of HVC neurons changed as a function of tutor exposure. Counterintuitively, tutor deprivation resulted in juvenile HVC neurons showing an adult-like phenotype not present in tutor-exposed juveniles. Biophysical models were developed to predict which ion channels were modulated by experience. The models indicate that tutor exposure transiently suppressed theIhand T-type Ca2+currents in HVC neurons that target the basal ganglia, whereas tutor exposure increased the resting membrane potential and decreased the spike amplitude in HVC neurons that drive singing. Our findings suggest that intrinsic plasticity may be part of the mechanism for auditory learning in the HVC. More broadly, models of learning and memory should consider intrinsic plasticity as a possible mechanism by which the nervous system encodes the lasting effects of experience.SIGNIFICANCE STATEMENTIt is well established that learning involves plasticity of the synapses between neurons. However, the activity of a neural circuit can also be dramatically altered by changes in the intrinsic properties (ion channels) of the component neurons. The present experiments show experience-dependent changes in the intrinsic physiology of neurons in the cortical premotor nucleus HVC (proper name) in juvenile zebra finches (Taeniopygia guttata) during auditory learning of a tutor's song. Tutor deprivation does not “arrest” development of intrinsic properties, but rather results in neurons with a premature adult-like physiological phenotype. It is possible that auditory learning involves a form of nonsynaptic plasticity and that experience-dependent suppression of specific ion channels may work in concert with synaptic plasticity to promote vocal learning. |
| Databáze: | OpenAIRE |
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