Poor Prognosis of Advanced Gastric Cancer with Metastatic Suprapancreatic Lymph Nodes
| Autor: | Masafumi Inomata, Toru Kusano, Hidefumi Shiroshita, Tsuyoshi Etoh, Seigo Kitano, Norio Shiraishi |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology medicine.medical_treatment Kaplan-Meier Estimate Surgical oncology Gastrectomy Stomach Neoplasms Internal medicine medicine Humans Neoplasm Invasiveness Pathological Survival rate Pancreas Aged Retrospective Studies Aged 80 and over Gastrointestinal Oncology business.industry Retrospective cohort study Middle Aged Prognosis Early Gastric Cancer Tumor Burden Survival Rate stomatognathic diseases medicine.anatomical_structure Lymphatic Metastasis Multivariate Analysis Blood Vessels Lymph Node Excision Surgery Female Lymph Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | Background Whether gastrectomy with D2 lymphadenectomy improves survival of patients with advanced gastric cancer (AGC) remains controversial. Few studies have described the pathological features of AGC with metastatic suprapancreatic lymph nodes (LN), which are the target of D2 lymphadenectomy. This study therefore aims to clarify the prognosis and clinical pathological features including the number and location of metastatic LN in AGC with metastatic suprapancreatic LN. Methods 406 patients with AGC, who underwent gastrectomy with D2 lymphadenectomy from 1982 to 2007 at Oita University, were reviewed retrospectively with regard to presence or absence of metastatic suprapancreatic LN. The pathological factors associated with AGC with metastatic suprapancreatic LN were examined by univariate and multivariate analysis. Results Of 362 patients with AGC, 78 had suprapancreatic LN metastasis (21.5 %), differing significantly in terms of presence of vascular invasion and having a larger number of metastatic perigastric LN in comparison with only metastatic perigastric LN on univariate analysis. According to multivariate analysis, they were associated with presence of vascular invasion and a large number of total metastatic LN (more than two; N2≤). The overall 5-year survival rate of the AGC with perigastric LN metastasis (station 1–7) group was 37.9 % and of the AGC with suprapancreatic LN metastasis group was 12.8 %. There were significant differences in each group (P |
| Databáze: | OpenAIRE |
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