Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
| Autor: | Viktor Ilyukha, Mark A. Zabezhinski, Vladimir N. Anisimov, Anna V. Semenchenko, Tatiana A. Lotosh, E. A. Khizhkin, A. V. Bukalev, I. A. Vinogradova |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Circadian disruption
Male medicine.medical_specialty Aging Light Photoperiod Longevity Biology medicine.disease_cause Pineal Gland Light at night Pineal gland Internal medicine Neoplasms medicine Animals Circadian rhythm photoperiodism Superoxide Dismutase Age Factors Cell Biology Catalase Circadian Rhythm Rats Regimen tumorigenesis Oxidative Stress medicine.anatomical_structure Endocrinology Light-at-night Female Carcinogenesis Oxidative stress life span Research Article |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. |
| Databáze: | OpenAIRE |
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