Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes
| Autor: | Juli Liu, Yucheng Zhang, Lei Han, Shuai Guo, Shiyong Wu, Emma Helen Doud, Cheng Wang, Hanying Chen, Michael Rubart-von der Lohe, Jun Wan, Lei Yang |
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| Rok vydání: | 2022 |
| Předmět: |
Pluripotent Stem Cells
Ivermectin SARS-CoV-2 Action Potentials COVID-19 Down-Regulation Apoptosis Cell Biology Phosphoproteins Biochemistry Up-Regulation Meclizine Adenosine Triphosphate Genetics Coronavirus Nucleocapsid Proteins Humans Myocytes Cardiac Protein Interaction Maps RNA Messenger Transcriptome Genome-Wide Association Study Signal Transduction Developmental Biology |
| Zdroj: | Stem Cell Reports. 17:522-537 |
| ISSN: | 2213-6711 |
| DOI: | 10.1016/j.stemcr.2022.01.014 |
| Popis: | Patients with coronavirus disease 2019 (COVID-19) commonly have manifestations of heart disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 27 proteins. Currently, SARS-CoV-2 gene-induced abnormalities of human heart muscle cells remain elusive. Here, we comprehensively characterized the detrimental effects of a SARS-CoV-2 gene, Orf9c, on human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) by preforming multi-omic analyses. Transcriptomic analyses of hPSC-CMs infected by SARS-CoV-2 with Orf9c overexpression (Orf9c |
| Databáze: | OpenAIRE |
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