Oxidative stress, aging, and diseases
| Autor: | Giulia Bulli, Luisa Aran, Francesco Curcio, Francesco Cacciatore, Gianluca Testa, Gennaro Russo, David Della-Morte, Pasquale Abete, Gaetano Gargiulo, Ilaria Liguori, Domenico Bonaduce |
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| Přispěvatelé: | Liguori, I, Russo, G, Curcio, F, Bulli, G, Aran, L, Della-Morte, D, Gargiulo, G, Testa, G, Cacciatore, F, Bonaduce, D, Abete, P. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Antioxidant medicine.medical_treatment Antioxidants Elderly Reactive nitrogen species Reactive oxygen species Biomarkers Chronic Disease Humans Reactive Oxygen Species Oxidative Stress Geriatrics and Gerontology Settore MED/09 Review Bioinformatics medicine.disease_cause elderly Pathogenesis 03 medical and health sciences chemistry.chemical_compound Medicine chemistry.chemical_classification reactive oxygen species business.industry RC952-954.6 antioxidants reactive nitrogen species Cancer General Medicine medicine.disease 030104 developmental biology chemistry Geriatrics Sarcopenia business Oxidative stress Kidney disease |
| Zdroj: | Clinical Interventions in Aging, Vol Volume 13, Pp 757-772 (2018) Clinical Interventions in Aging |
| ISSN: | 1178-1998 |
| Popis: | Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest. Keywords: elderly, reactive oxygen species, reactive nitrogen species, antioxidants |
| Databáze: | OpenAIRE |
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