Correlation between serum S100β protein levels and cognitive dysfunction in patients with cerebral small vessel disease: a case–control study

Autor: Fei Wang, Zhi-Rong Zou, Dong Yuan, Tao Sun, Li Zhang, Xun Chen, Yi Gong, Hualin Yu
Rok vydání: 2017
Předmět:
Serum S100β
Male
0301 basic medicine
medicine.medical_specialty
Biophysics
Cerebral small vessel disease
Enzyme-Linked Immunosorbent Assay
Montreal cognitive assessment
S100 Calcium Binding Protein beta Subunit
Neuropsychological Tests
Logistic regression
Biochemistry
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Cognitive dysfunction
Risk Factors
Internal medicine
medicine
Humans
Dementia
Mini-mental state examination
Molecular Biology
Research Articles
Aged
Mini–Mental State Examination
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Case-control study
Montreal Cognitive Assessment
Cognition
Cholesterol
LDL
Cell Biology
Middle Aged
medicine.disease
Logistic Models
030104 developmental biology
Blood pressure
ROC Curve
Case-Control Studies
Cerebral Small Vessel Diseases
Hypertension
Female
business
030217 neurology & neurosurgery
Research Article
Zdroj: Bioscience Reports
ISSN: 1573-4935
0144-8463
DOI: 10.1042/bsr20160446
Popis: The present study was designed to explore the correlation between serum S100β levels and cognitive dysfunction in patients with cerebral small vessel disease (SVD). A total of 172 SVD patients participated in the study, and they were assigned to patients with no cognitive impairment (NCI group) and those with vascular cognitive impairment no dementia (VCIND group). In total, 105 people were recruited into the normal control group. Serum S100β protein level was detected by ELISA. A receiver operating characteristic (ROC) curve was employed for the predictive value of serum S100β in diagnosing SVD with cognitive dysfunction. Pearson correlation analysis was used to examine the association of S100β level with mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) and the association of S100β levels with hypertension. Logistic regression analysis was used to analyze risk factors of SVD. The serum S100β levels in the VCIND group were higher than those in the NCI and normal control groups. Logistic regression analysis revealed that a high serum S100β protein level, hypertension, and high low density lipoprotein-cholesterol (LDL-C) level were the independent risk factors for SVD. In addition, hypertension patients showed higher S100β levels than those with normal blood pressure and the normal control group, and there was a positive correlation between S100β level and blood pressure. The concentration of serum S100β level was related to impairment of cognition function of VCIND patients, therefore, early detection of serum S100β was of great value for diagnosis of SVD.
Databáze: OpenAIRE
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