Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature
| Autor: | Jens Gieffers, Friedhelm Sayk, S Ehlers, Jan Rupp, G. van Zandbergen, S Krüger, Werner Solbach, Matthias Maass |
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| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Phagocyte Lymphoid Tissue Bacteremia Spleen medicine.disease_cause Monocytes Capillary Permeability Cell Movement Macrophages Alveolar medicine Animals Chlamydophila Infections Lung Respiratory Tract Infections Aorta Phagocytes Chlamydia business.industry Epithelial Cells Chlamydophila pneumoniae medicine.disease respiratory tract diseases Pulmonary Alveoli Disease Models Animal Chronic infection Lymphatic system medicine.anatomical_structure Immunology Blood Vessels Female Rabbits business Granulocytes Respiratory tract |
| Zdroj: | European Respiratory Journal. 23:506-510 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.04.00093304 |
| Popis: | Chlamydia pneumoniae, a major cause of community-acquired pneumonia, primarily infects the respiratory tract. Chronic infection of nonrespiratory sites, such as the vascular wall, the brain or blood monocytes, requires evasion from the lungs and spreading via the bloodstream. The cell types involved in dissemination are insufficiently characterised. In this study, New Zealand White rabbits were infected intratracheally with C. pneumoniae, and lung manifestation and systemic dissemination were monitored by polymerase chain reaction and immunohistochemistry. Infection of the lungs was characterised by an early phase dominated by granulocytes and a late phase dominated by alveolar macrophages (AM). Granulocytes, AM and alveolar epithelial cells acted as host cells for chlamydiae, which remained detectable for up to 8 weeks. AM transported the pathogen to the peribronchiolar lymphatic tissue, and subsequently C. pneumoniae entered the spleen and the aorta via dissemination by peripheral blood monocytes. In conclusion, Chlamydia pneumoniae-infected alveolar macrophages transmigrate through the mucosal barrier, and give the pathogen access to the lymphatic system and the systemic circulation. Infected peripheral blood monocytes are the vector system within the bloodstream and transmit the infection to the vascular wall. This is the first description of granulocytes acting as a reservoir for Chlamydia pneumoniae early in infection. |
| Databáze: | OpenAIRE |
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