Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction
| Autor: | P McNair, Teis Andersen, L Breum, Ib Transbøl, Lars Hyldstrup |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Diet Reducing Bone density Endocrinology Diabetes and Metabolism Osteocalcin Bone and Bones Bone resorption Bone remodeling chemistry.chemical_compound Hydroxyproline Calcification Physiologic Endocrinology Bone Density Weight loss Internal medicine Weight Loss medicine Humans Longitudinal Studies Bone Resorption Creatinine business.industry General Medicine Middle Aged Alkaline Phosphatase medicine.disease Obesity Obesity Morbid Cross-Sectional Studies Premenopause chemistry Female medicine.symptom business Calcification |
| Zdroj: | Acta Endocrinologica. 129:393-398 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1290393 |
| Popis: | A non-invasive evaluation of bone metabolism was performed in 44 morbidly obese patients before and after a mean weight loss of 22.4 kg (range 7.9–43.4 kg) after 2 months and a further weight loss of 7.3 kg after 8 months (0.8–20.0 kg). This weight reduction was obtained by a nutritionally adequate very-low-calorie diet. Before treatment the bone mineral content of the distal forearm was increased compared to normals (51.9 U vs 43.7 U, p−3 vs 16.7 molar ratio × 10−3, NS). After 2 months, the bone mineral content had declined by 3.3%. Serum alkaline phosphatase remained unchanged (187.8 U/l vs 186.9 U/l, NS) but serum osteocalcin demonstrated a significant rise (3.94 nmol/l vs 10.53 nmol/l, p−3 vs 25.2 molar ratio × 10−3, p−3 to 30.1 molar ratio × 10−3, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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