Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles
| Autor: | Daysi Diaz-Diestra, Gerardo Morell, Juan Beltran-Huarac, Bibek Thapa, Brad R. Weiner |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Iron oxide Nanochemistry Ether 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Nuclear magnetic resonance T2 relaxivity PEG ratio MRI contrast agents lcsh:TA401-492 Molecule General Materials Science Magnetic iron oxide nanopaticles chemistry.chemical_classification T 2 relaxivity Nano Express Biomolecule PEGylation 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences 3. Good health chemistry lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Nanoscale Research Letters, Vol 12, Iss 1, Pp 1-13 (2017) Nanoscale Research Letters |
| ISSN: | 1556-276X 1931-7573 |
| Popis: | Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM−1s−1, which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex. They do not induce a toxic response for Fe concentrations below 2.5 mM, as tested on four different cell lines with and without an external magnetic field. Magnetic resonance phantom imaging studies show that anchor-free PEG-SPIONs produce a significant contrast in the range of 0.1–0.4 [Fe] mM. Our findings reveal that the PEG molecules attached to the cores immobilize water molecules in large regions of ~85 nm, which would lead to blood half-life of a few tens of minutes. This piece of research represents a step forward in the development of next-generation CAs for nascent-stage cancer detection. Graphical Abstract Contrast-probed anchor-free PEGylated iron oxide contrast agent Electronic supplementary material The online version of this article (doi:10.1186/s11671-017-2084-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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