| Autor: |
Georg Deutsch, Alisa Stephens, Robert Dayton, Carol S. North, Frank F. Tu, Yanli Wang, Nancy Robinson, Gerald L. Andriole, Susan K. Lutgendorf, Yi Luo, Karen R. Jonscher, Clara Grayhack, Wei Yang, Jeffry R. Alger, Eric Ichesco, Jennifer T. Anger, Ted Barrell, Holly T. Sullivan, Fornessa Randal, Lisa A. Kilpatrick, Theresa Spitznagle, Jean Michniewicz, J. Quentin Clemens, Noorulain Noor, John T. Farrar, Jeena Cha, Philip M. Hanno, Kevin A. Johnson, Rebecca L. Bristol, Siobhan Sutcliffe, Claire C. Yang, Jane L. Miller, Katherine A. Scott, Garth D. Ehrlich, Stephanie Richey, Michel A. Pontari, Xingmei Wang, Susan O. Ross, Rebecca McCue, Sandra H. Berry, Monisha Sachdev, Laura Gallagher, M. Scott Lucia, TJ Sundsvold, Sean Mackey, Daniel J. Clauw, David Cella, Kelly Robertson, Tamara Bavendam, Jason J. Kutch, Mary Eno, Michael A. O’Donnell, Nuwanthi Heendeniya, Rachel R. Moericke, Ben Ellingson, Robert M. Moldwin, John W. Kusek, John N. Krieger, Epifanio Bagarinao, Suzanne R. Smith, Graham A. Colditz, David J. Klumpp, Barbara Ziegler, Vincent Funari, Karl J. Kreder, Eric Strachan, Thomas Jemielita, Barry A. Hong, Bruce D. Naliboff, H. Henry Lai, Lauren C. Foster, Richard E. Harris, Steve Harte, Keith R. Solomon, Niloofar Afari, Catherine S. Bradley, J. Richard Landis, Ro Pauline Doe, David R. Williams, Thomas M. Hooton, Ann Oldendorf, Alisa J. Stephens-Shields, Hanno Steen, A. Nilakantan, Sandra Smith, Emily Hubbard, Todd B. Parrish, Cody Ashe-McNalley, Dedra Buchwald, Vivien Gardner, Darlene S. Marko, Roberta Spiro, Kris Greiner, Richard Gershon, Chris Mullins, James W. Griffith, Robert W. Gereau, Michael F. Freeman, Apkar Vania Apkarian, Suzie As-Sanie, Anthony J. Schaeffer, Megan E. Halvorson, Emeran A. Mayer, John W. Froehlich, Timothy J. Ness, Andrew C. Briscoe, Colleen Fitzgerald, Jennifer S. Labus, R. Storey Wilson, Tamara Howard, Charles J. Heckman, M. C. Jiang, Melissa A. Farmer, Karyn S. Eilber, David Briscoe, Marsha A. Moses, Xiaoling Hou, Cara Kulbacki, Richard S. Lee, Katherine T. Martucci, J. Curtis Nickel, Larissa V. Rodriguez, Jeffrey P. Henderson, Jayoung Kim, Andrea A. Osypuk, Jennifer Van Eyk, Ziya Kirkali, Adrie van Bokhoven, Laurie Keefer, Adam S. Curatolo |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Popis: |
We examined symptom variability in men and women with urological chronic pelvic pain syndrome. We describe symptom fluctuations as related to early symptom regression and its effect on estimated 1-year symptom change. We also describe a method to quantify patient specific symptom variability.Symptoms were assessed biweekly in 424 subjects with urological chronic pelvic pain syndrome during 1 year. To evaluate the impact of early symptom regression subjects were classified as improved, no change or worse according to the rate of change using 1) all data, 2) excluding week 0 and 3) excluding weeks 0 and 2. Patient specific, time varying variability was calculated at each interval using a sliding window approach. Patients were classified as high, medium or low variability at each time and ultimately as high or low variability overall based on the variability for the majority of contacts.Prior to excluding early weeks to adjust for early symptom regression 25% to 38% and 5% to 6% of patients were classified as improved and worse, respectively. After adjustment the percent of patients who were improved or worse ranged from 15% to 25% and 6% to 9%, respectively. High and low variability phenotypes were each identified in 25% to 30% of participants.Patients with urological chronic pelvic pain syndrome show symptom variability. At study enrollment patients had worse symptoms on average, resulting in a regression effect that influenced the estimated proportion of those who were improved or worse. Prospective studies should include a run-in period to account for regression to the mean and other causes of early symptom regression. Further, symptom variability may be quantified and used to characterize longitudinal symptom profiles of urological chronic pelvic pain syndrome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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