Microglia modulate the structure and function of the hippocampus after early-life seizures
| Autor: | Megumi Andoh, Yuji Ikegaya, Ryuta Koyama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Brain Structure and Function Hippocampus Cell Communication Epileptogenesis Seizures Febrile Temporal lobe Mice 03 medical and health sciences Epilepsy 0302 clinical medicine Risk Factors Febrile seizure Animals Humans Medicine Age of Onset Neurons Pharmacology Microglia business.industry Dentate gyrus lcsh:RM1-950 Age Factors medicine.disease Synapse Rats Disease Models Animal lcsh:Therapeutics. Pharmacology 030104 developmental biology medicine.anatomical_structure Epilepsy Temporal Lobe nervous system Dentate Gyrus Synapses Molecular Medicine business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Pharmacological Sciences, Vol 144, Iss 4, Pp 212-217 (2020) |
| ISSN: | 1347-8613 |
| Popis: | The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings suggest that microglia may contribute to the onset and aggravation of epilepsy; however, direct evidence for microglial involvement or the underlying mechanisms by which this occurs remain to be fully discovered. To date, neuron–microglia interactions have been vigorously studied in adult epilepsy models; such studies have clarified microglial responses to excessive synchronous firing of neurons. In contrast, the role of microglia in the postnatal brain of patients with epileptic seizures remain largely unclear. Some early-life seizures, such as complex febrile seizures, have been shown to cause structural and functional changes in the brain, which is a risk factor for future development of epilepsy. Because brain structure and function are actively modulated by microglia in both health and disease, it is essential to clarify the role of microglia in early-life seizures and its impact on epileptogenesis. |
| Databáze: | OpenAIRE |
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