COVID-19 and Parkinson’s disease:Shared inflammatory pathways under oxidative stress
| Autor: | Bushra Y. Ahmed, Gerta Cami-Kobeci, Donika Klenja, Najma Janjua, Zahara Latif Chaudhry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Parkinson's disease
viruses caspase Stimulation Disease medicine.disease_cause Article lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine inhibitors medicine oxidative stress Progenitor cell lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Caspase 030304 developmental biology Coronavirus 0303 health sciences biology business.industry SARS-CoV-2 General Neuroscience nuclear factor kappa B ((NFκB)) apoptosis virus diseases Covid19 medicine.disease 6OHDA Apoptosis Immunology biology.protein Parkinson’s disease nuclear factor kappa B (NFκB) business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Chaudhry, Z L, Klenja, D, Janjua, N, Cami-Kobeci, G & Ahmad, B Y 2020, ' COVID-19 and Parkinson’s disease : Shared inflammatory pathways under oxidative stress ', Brain Sciences, vol. 10, no. 11, 807 . https://doi.org/10.3390/brainsci10110807 Brain Sciences, Vol 10, Iss 807, p 807 (2020) Brain Sciences Volume 10 Issue 11 |
| DOI: | 10.3390/brainsci10110807 |
| Popis: | The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson&rsquo s disease (PD). Increasing evidence suggests an involvement of oxidative stress and contribution of NF&kappa B in the development of both COVID-19 and PD. Although, it is early to identify if SARS-CoV-2 led infection enhances PD complications, it is likely that oxidative stress may exacerbate PD progression in COVID-19 affected individuals and/or vice versa. In the current study, we sought to investigate whether NF&kappa B-associated inflammatory pathways following oxidative stress in SARS-CoV-2 and PD patients are correlated. Toward this goal, we have integrated bioinformatics analysis obtained from Basic Local Alignment Search Tool of Protein Sequence Database (BLASTP) search for similarities of SARS-CoV-2 proteins against human proteome, literature review, and laboratory data obtained in a human cell model of PD. A Parkinson&rsquo s like state was created in 6-hydroxydopamine (6OHDA)-induced differentiated dopamine-containing neurons (dDCNs) obtained from an immortalized human neural progenitor cell line derived from the ventral mesencephalon region of the brain (ReNVM). The results indicated that SARS-CoV-2 infection and 6OHDA-induced toxicity triggered stimulation of caspases-2, -3 and -8 via the NF&kappa B pathway resulting in the death of dDCNs. Furthermore, specific inhibitors for NF&kappa B and studied caspases reduced the death of stressed dDCNs. The findings suggest that knowledge of the selective inhibition of caspases and NF&kappa B activation may contribute to the development of potential therapeutic approaches for the treatment of COVID-19 and PD. |
| Databáze: | OpenAIRE |
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