Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches
| Autor: | Jae Il Shin, Daniel Fernando Pereira Vasconcelos, Even Herlany Pereira Alves, Camila Valente Smith, Anna Carolina Toledo da Cunha Pereira, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, Reyce Santos Koga |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Bayesian probability Interleukin-1beta Disease Bioinformatics Biochemistry Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic medicine Odds Ratio Immunology and Allergy Humans False Positive Reactions Genetic Predisposition to Disease Allele Molecular Biology Probability Periodontitis business.industry Bayes Theorem Hematology Odds ratio medicine.disease Chronic periodontitis 030104 developmental biology IL1A 030220 oncology & carcinogenesis Chronic Periodontitis IL17A Inflammation Mediators business Biomarkers |
| Zdroj: | Cytokine. 138 |
| ISSN: | 1096-0023 |
| Popis: | Periodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility. |
| Databáze: | OpenAIRE |
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