Perineural invasion/lymphovascular invasion double positive predicts distant metastasis and poor survival in T3–4 oral squamous cell carcinoma
| Autor: | Chia-Fan Chang, Kuan Chung Ting, Pen Yuan Chu, Wing Yin Li, Yi Fen Wang, Tsung Lun Lee, Shyh Kuan Tai |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphovascular invasion Science Perineural invasion Double negative Diseases Kaplan-Meier Estimate Gastroenterology Article Metastasis Internal medicine medicine Adjuvant therapy Humans Neoplasm Invasiveness Public Health Surveillance Basal cell Aged Neoplasm Staging Aged 80 and over Multidisciplinary business.industry Distant metastasis Middle Aged Prognosis medicine.disease Survival Analysis stomatognathic diseases Oncology Lymphatic Metastasis Multivariate Analysis Carcinoma Squamous Cell Curative surgery Medicine Female Mouth Neoplasms business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-99280-2 |
| Popis: | Postoperative adjuvant therapy has been indicated by advanced T classification for T3–4 oral squamous cell carcinoma (OSCC) and the significance of perineural invasion (PNI) and lymphovascular invasion (LVI) in treatment for T3–4 OSCC remains unclear. Ninety-eight cumulative patients with T3–4 OSCC who underwent curative surgery between Jan 2002 and Dec 2010 were recruited and analyzed. Twenty-seven (27.6%) patients were PNI/LVI double positive. PNI/LVI double positive demonstrated independent predictive values for higher neck metastasis (LN+), higher distant metastasis (DM) and low 5-year disease-specific survival (DSS) rates (p p = 0.017, and p |
| Databáze: | OpenAIRE |
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