Increased sclerostin and bone turnover after diet-induced weight loss in type 2 diabetes: a post hoc analysis of the MADIAB trial
| Autor: | Rossella Del Toro, Sara Fallucca, Antonio Di Mauro, Yeganeh Manon Khazrai, Laura Dugo, Rocky Strollo, Paolo Pozzilli, Nicola Napoli, Andreea Soare, Mario Pianesi, Maria Giovanna Belluomo, Andrea Palermo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetic Markers Male medicine.medical_specialty Diet Reducing Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Bone resorption Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Weight loss Diabetes mellitus Internal medicine Weight Loss medicine Humans Obesity education Adaptor Proteins Signal Transducing Aged education.field_of_study business.industry Body Weight Macrobiotic diet Middle Aged Overweight medicine.disease 030104 developmental biology Treatment Outcome chemistry Diabetes Mellitus Type 2 Bone Morphogenetic Proteins Sclerostin Female Bone Remodeling medicine.symptom business Body mass index Biomarkers |
| Zdroj: | Endocrine. 56(3) |
| ISSN: | 1559-0100 |
| Popis: | Sclerostin has been directly related to bone turnover increase in dietary-induced weight loss in non-diabetics. This has not been studied in type 2 diabetes, a condition characterized by increased circulating sclerostin and impaired bone turnover. To study the effect of dietary weight loss and quality of the dietary intervention on changes of sclerostin and bone turnover markers in type 2 diabetes. This was a post-hoc analysis of the MADIAB trial, a 21-day randomized controlled trial on overweight/obese type 2 diabetes patients. Patients were randomly assigned 1:1 to the Ma-Pi2 macrobiotic diet or a control diet based on dietary guidelines for type 2 diabetes. Serum sclerostin and circulating markers of bone resorption and formation (P1NP) were measured by enzyme linked immunosorbent assay in 40 subjects (1:1) at baseline and after 21 days treatment. Both Ma-Pi2 and the control diet groups had significant decreases in body weight (6.0 ± 0.2 vs. 3.2 ± 0.1 %, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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