Histological tumor response to neoadjuvant chemotherapy correlates to Immunoscore in colorectal cancer liver metastases patients
| Autor: | Jinhong Chen, Xiaochen Ma, Xiang-Yu Wang, Rui Zhang, Jie Fan, Guo Zhang, Zhenmei Chen, Yitong Li, Chong Zhang, Jia-Hao Han |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer medicine.medical_treatment Tumor response Gastroenterology Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Overall survival Humans Tumor Regression Grade Chemotherapy Framingham Risk Score business.industry Liver Neoplasms General Medicine Middle Aged Postoperative survival medicine.disease Prognosis Neoadjuvant Therapy Survival Rate Oncology Surgery Female business Colorectal Neoplasms Clinical risk factor Biomarkers Follow-Up Studies |
| Zdroj: | Journal of surgical oncologyREFERENCES. 124(8) |
| ISSN: | 1096-9098 |
| Popis: | BACKGROUND This study investigated the correlation between tumor regression grade (TRG) score and Immunoscore, and prognostic values of TRG score and a risk score in colorectal cancer liver metastases (CRLMs) patients after neoadjuvant chemotherapy. METHODS Patients undergoing neoadjuvant chemotherapy from 2014 to 2019 were selected. TRG score and Immunoscore were evaluated in 200 CRLMs. A risk score combining TRG score, Immunoscore, and clinical risk score (CRS) was defined and divided patients into the low-, medium-, and high-risk groups. Differences in relapse-free survival (RFS) and overall survival (OS) between groups were determined. RESULTS The densities of CD3+ and CD8+ immune cells were higher in TRG1-3 group than in TRG4-5 group, and the ratio of high Immunoscores was higher in TRG1-3 group than in TRG4-5 group (60.0% vs. 15.8%, p |
| Databáze: | OpenAIRE |
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