Placental ABC Transporters: Biological Impact and Pharmaceutical Significance
| Autor: | Soniya Vaidya, Phillip M. Gerk, Kenneth L. Audus, Abner N. Nyandege, Marie V. St-Pierre, Andrei M. Mikheev, Kelly E. Desino, Jashvant D. Unadkat, Anand A. Joshi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drugs of abuse ATP Binding Cassette Transporter Subfamily B Abcg2 Placenta Pharmaceutical Science ATP-binding cassette transporter Bioinformatics Article Xenobiotics 03 medical and health sciences Pregnancy medicine Animals Humans Pharmacology (medical) Maternal-Fetal Exchange P-glycoprotein Pharmacology Fetus Polymorphism Genetic biology Organic Chemistry Placental expression Biological Transport Human placenta Hormones 030104 developmental biology medicine.anatomical_structure Pharmaceutical Preparations Biochemistry biology.protein Cytokines Molecular Medicine ATP-Binding Cassette Transporters Female Multidrug Resistance-Associated Proteins Biotechnology |
| Zdroj: | Pharmaceutical Research. 33:2847-2878 |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-016-2028-8 |
| Popis: | The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy. |
| Databáze: | OpenAIRE |
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