Supraamphiphilic Systems Based on Metallosurfactant and Calix[4]resorcinol: Self-Assembly and Drug Delivery Potential
| Autor: | Sufia Ziganshina, Tatiana Yu. Sergeeva, Irek R. Nizameev, Anastasiia S. Sapunova, Nadezda Kashapova, B. I. Gareev, Svetlana S. Lukashenko, Alexandra D. Voloshina, Yuliya S. Razuvayeva, Albina Y. Ziganshina, Vadim V. Salnikov, Ruslan R. Kashapov, Lucia Ya. Zakharova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antineoplastic Agents
Resorcinol Microscopy Atomic Force Inorganic Chemistry Inhibitory Concentration 50 Surface-Active Agents chemistry.chemical_compound Drug Delivery Systems Microscopy Electron Transmission Pulmonary surfactant Amphiphile Calixarene Organometallic Compounds Humans Physical and Theoretical Chemistry Molecular Structure Liver cell Resorcinols Combinatorial chemistry chemistry Drug delivery Hepatocytes Electrophoretic light scattering Self-assembly Calixarenes Cisplatin HeLa Cells |
| Zdroj: | Inorganic Chemistry. 59:18276-18286 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | Metallic amphiphiles are used as building blocks in the construction of nanoscale superstructures, where the hydrophobic effects induce the self-assembly of the nanoparticles of interest. However, the influence of synergizing multiple chemical interactions on an effective design of these structures mostly remains an open question. In this regard, supraamphiphilic systems based on flexible surfactant molecules and rigid macrocycles are being actively developed, but there are few works on the interaction between metallosurfactants and macrocycles. In the present work, the self-assembly and biological properties of a metallosurfactant with calixarene were studied for the first time. The metallosurfactant, a complex between lanthanum nitrate and two 4-aza-1-hexadecylazoniabicyclo[2.2.2]octane bromide units, and calix[4]resorcinol containing sulfonate groups on the upper rim were used to form a novel supraamphiphilic composition. The system formed was studied using a variety of physicochemical methods, including spectrophotometry, NMR, XRF, and dynamic and electrophoretic light scattering. It was found that the most optimal tetraanionic calix[4]resorcinol to dicationic metallosurfactant molar ratio, leading to mixed aggregation upon ion pair complexation, is 2:3. The mixed aggregates formed in the pentamolar concentration range were able to encapsulate hydrophilic substrates, including the anticancer drug cisplatin, the pure form of which is more cytotoxic toward healthy cells than toward diseased cells. Interestingly, the drug loaded into the macrocycle-metallosurfactant particles was less cytotoxic to a healthy Chang liver cell line and more cytotoxic to tumor M-HeLa cells. This selectivity depends on the amount of cisplatin added. The more drug is added to the macrocycle-metallosurfactant composition, the greater the biological activity against cancer cells. Taking into account that the appearance of resistance of cancer cells to drugs, especially to cisplatin, is one of the most important problems in treatment, the results of this work envisage the potential application of a mixed macrocycle-metallosurfactant system for the design of therapeutic cisplatin compositions. |
| Databáze: | OpenAIRE |
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