Sex steroids receptors, hypertension, and vascular ageing
Autor: | Rhian M. Touyz, Augusto C. Montezano, Helen Casey, Paul J. Connelly, Christian Delles |
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Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine Aging Receptors Steroid Adolescent medicine.drug_class Physiology Disease 030204 cardiovascular system & hematology Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Internal Medicine medicine Humans Receptor Aldosterone business.industry Sex hormone receptor Androgen receptor 030104 developmental biology Blood pressure Estrogen Sex steroid Hypertension Female business Hormone |
Zdroj: | Journal of Human Hypertension. 36:120-125 |
ISSN: | 1476-5527 0950-9240 |
Popis: | Sex hormone receptors are expressed throughout the vasculature and play an important role in the modulation of blood pressure in health and disease. The functions of these receptors may be important in the understanding of sexual dimorphism observed in the pathophysiology of both hypertension and vascular ageing. The interconnectivity of these factors can be exemplified in postmenopausal females, who with age and estrogen deprivation, surpass males with regard to hypertension prevalence, despite experiencing significantly less disease burden in their estrogen replete youth. Estrogen and androgen receptors mediate their actions via direct genomic effects or rapid non-genomic signaling, involving a host of mediators. The expression and subtype composition of these receptors changes through the lifespan in response to age, disease and hormonal exposure. These factors may promote sex steroid receptor-mediated alterations to the Renin–Angiotensin–Aldosterone System (RAAS), and increases in oxidative stress and inflammation, thereby contributing to the development of hypertension and vascular injury with age. |
Databáze: | OpenAIRE |
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