Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides
| Autor: | Ernesto Sánchez-Mendoza, Diana Elizabeth Martínez-González, Cuauhtémoc Pérez-González, Salud Pérez-Gutiérrez, Miguel Angel Zavala-Sánchez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.drug_class Stereochemistry polymer Anti-Inflammatory Agents Pharmaceutical Science Random hexamer peroxide Peroxide Anti-inflammatory Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Mice Structure-Activity Relationship lcsh:Organic chemistry Ethers Cyclic Edema Drug Discovery medicine Structure–activity relationship Animals Physical and Theoretical Chemistry Rats Wistar anti-inflammatory activity biology Chemistry Krameria Plant Extracts kramecyne Organic Chemistry biology.organism_classification Acute toxicity Peroxides Rats Chemistry (miscellaneous) Molecular Medicine Methanol medicine.symptom Krameriaceae Nuclear chemistry |
| Zdroj: | Molecules; Volume 17; Issue 2; Pages: 2049-2057 Molecules Molecules, Vol 17, Iss 2, Pp 2049-2057 (2012) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules17022049 |
| Popis: | In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg. |
| Databáze: | OpenAIRE |
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