Is homocysteine toxic in uremia?
| Autor: | Maria Grazia Luciano, Paola Pulzella, Ersilia Satta, Rosanna Capasso, Cinzia Lombardi, Diego Ingrosso, Natale G. De Santo, Alessandra F. Perna |
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| Přispěvatelé: | Perna, Alessandra, Luciano, Mg, Pulzella, P, Satta, E, Capasso, R, Lombardi, C, Ingrosso, Diego, DE SANTO, Ng |
| Rok vydání: | 2007 |
| Předmět: |
Hyperhomocysteinemia
medicine.medical_specialty Homocysteine medicine.medical_treatment Population Myocardial Infarction Medicine (miscellaneous) Disease Bioinformatics chemistry.chemical_compound Folic Acid Recurrence Reference Values Renal Dialysis Risk Factors Internal medicine medicine Humans Risk factor education Retrospective Studies Uremia education.field_of_study Nutrition and Dietetics Mechanism (biology) business.industry medicine.disease Acetylcysteine Endocrinology chemistry Nephrology Cardiovascular Diseases Kidney Failure Chronic Hemodialysis Antitoxins business |
| Zdroj: | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 18(1) |
| ISSN: | 1532-8503 |
| Popis: | High levels of homocysteine have been implicated as a cardiovascular risk factor in the general population and in patients with chronic renal failure, and particularly patients on hemodialysis. To classify a risk factor as causally related to a certain disease, both strong epidemiologic data and sound basic-science studies establishing a mechanism are needed. Among the latter, the hypomethylation of proteins and DNA, and protein homocysteinylation, have been investigated in uremia, providing for an array of toxic effects in this disease. © 2008 National Kidney Foundation, Inc. |
| Databáze: | OpenAIRE |
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