Exposure to sucrose during periods of withdrawal does not reduce cocaine-seeking behavior in rats
| Autor: | Marcello Solinas, Céline Nicolas, Claire Lafay-Chebassier |
|---|---|
| Přispěvatelé: | Laboratoire de neurosciences expérimentales et cliniques (LNEC), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pharmacologie clinique et de sensibilisation [CHU Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), This work was supported by the Institute National de la Santé et de la Recherche Médicale, le Centre National pour la Recherche Scientifique, University of Poitiers, Mission Interministérielle de la Lutte contre les Drogues et la Toxicomanie (MILDT-INSERM-INCA 2007–2009) and the Contrat de Projet Etat Région (CPER) no. 5. Research. C.N. was recipient of PhD fellowship by the Poitou-Charentes region. We thank Michael Bardo and Nathalie Thiriet for comments on the manuscript., SOLINAS, Marcello |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Sucrose Drugs of abuse medicine.medical_treatment media_common.quotation_subject Drug-Seeking Behavior [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Self Administration Cocaine related disorders Drug seeking Pharmacology Article Rats Sprague-Dawley Cocaine-Related Disorders 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Saline media_common 2. Zero hunger Multidisciplinary [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior business.industry Abstinence Behavior Addictive 030104 developmental biology chemistry Self-administration business 030217 neurology & neurosurgery Cocaine seeking |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2016, 6 (1), pp.23272. ⟨10.1038/srep23272⟩ |
| ISSN: | 2045-2322 |
| Popis: | Concomitant access to drugs of abuse and alternative rewards such as sucrose has been shown to decrease addiction-related behaviors in animals. Here we investigated whether access to sucrose during abstinence in contexts that are temporally and physically distinct from drug-related contexts could reduce subsequent drug seeking. In addition, we investigated whether a history of cocaine self-administration would alter the rewarding effects of sucrose. Rats self-administered cocaine for ten sessions, while yoked-saline rats received only saline injections and then we subjected them to a 30-day withdrawal period during which they had access to water and sucrose continuously or intermittently according to a schedule that induces binge-drinking behavior. At the end of the withdrawal period, rats were tested for cocaine seeking behavior during a single 6 h session. We found that exposure to cocaine increased sucrose consumption only when rats had intermittent access to sucrose, but exposure to sucrose did not alter drug seeking regardless of the schedule of access. These results suggest that exposure to cocaine cross-sensitizes to the rewarding effects of sucrose, but exposure to sucrose during abstinence, temporally and physically distinct from drug-related environments, does not to reduce drug seeking. |
| Databáze: | OpenAIRE |
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